node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDOA | ALDOB | ENSP00000336927 | ENSP00000363988 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | aldolase B, fructose-bisphosphate | 0.829 |
ALDOA | ALDOC | ENSP00000336927 | ENSP00000226253 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | aldolase C, fructose-bisphosphate | 0.981 |
ALDOA | ENO3 | ENSP00000336927 | ENSP00000324105 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.985 |
ALDOA | GAPDH | ENSP00000336927 | ENSP00000229239 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.984 |
ALDOA | GPI | ENSP00000336927 | ENSP00000405573 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.980 |
ALDOA | PGAM1 | ENSP00000336927 | ENSP00000359991 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | phosphoglycerate mutase 1 (brain); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity | 0.948 |
ALDOA | PGK1 | ENSP00000336927 | ENSP00000362413 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) | 0.897 |
ALDOA | PGK2 | ENSP00000336927 | ENSP00000305995 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | phosphoglycerate kinase 2 | 0.844 |
ALDOA | UBC | ENSP00000336927 | ENSP00000344818 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | ubiquitin C | 0.999 |
ALDOB | ALDOA | ENSP00000363988 | ENSP00000336927 | aldolase B, fructose-bisphosphate | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | 0.829 |
ALDOB | ALDOC | ENSP00000363988 | ENSP00000226253 | aldolase B, fructose-bisphosphate | aldolase C, fructose-bisphosphate | 0.805 |
ALDOB | ENO3 | ENSP00000363988 | ENSP00000324105 | aldolase B, fructose-bisphosphate | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.981 |
ALDOB | GAPDH | ENSP00000363988 | ENSP00000229239 | aldolase B, fructose-bisphosphate | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.982 |
ALDOB | GPI | ENSP00000363988 | ENSP00000405573 | aldolase B, fructose-bisphosphate | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.980 |
ALDOB | PGAM1 | ENSP00000363988 | ENSP00000359991 | aldolase B, fructose-bisphosphate | phosphoglycerate mutase 1 (brain); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity | 0.930 |
ALDOB | PGK1 | ENSP00000363988 | ENSP00000362413 | aldolase B, fructose-bisphosphate | phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) | 0.822 |
ALDOB | PGK2 | ENSP00000363988 | ENSP00000305995 | aldolase B, fructose-bisphosphate | phosphoglycerate kinase 2 | 0.845 |
ALDOB | UBC | ENSP00000363988 | ENSP00000344818 | aldolase B, fructose-bisphosphate | ubiquitin C | 0.752 |
ALDOC | ALDOA | ENSP00000226253 | ENSP00000336927 | aldolase C, fructose-bisphosphate | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | 0.981 |
ALDOC | ALDOB | ENSP00000226253 | ENSP00000363988 | aldolase C, fructose-bisphosphate | aldolase B, fructose-bisphosphate | 0.805 |