EFHC1 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EFHC1

EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death (640 aa)

Predicted Functional Partners:

CACNA1E

0.886

CLCN2

0.803

SPAG6

0.698

CACNB4

0.689

BRD2

0.688

ZNF536

0.635

GABRA1

0.628

ARL13B

0.621

GABRD

0.606

TEKT1

0.602

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL13B	EFHC1	ENSP00000377769	ENSP00000360107	ADP-ribosylation factor-like 13B	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	0.621
BRD2	EFHC1	ENSP00000378702	ENSP00000360107	bromodomain containing 2	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	0.688
CACNA1E	CACNB4	ENSP00000356545	ENSP00000438949	calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...]	calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	0.804
CACNA1E	EFHC1	ENSP00000356545	ENSP00000360107	calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...]	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	0.886
CACNB4	CACNA1E	ENSP00000438949	ENSP00000356545	calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...]	0.804
CACNB4	CLCN2	ENSP00000438949	ENSP00000265593	calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport	0.659
CACNB4	EFHC1	ENSP00000438949	ENSP00000360107	calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	0.689
CACNB4	GABRA1	ENSP00000438949	ENSP00000023897	calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	gamma-aminobutyric acid (GABA) A receptor, alpha 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.440
CACNB4	GABRD	ENSP00000438949	ENSP00000367848	calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.561
CLCN2	CACNB4	ENSP00000265593	ENSP00000438949	chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport	calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	0.659
CLCN2	EFHC1	ENSP00000265593	ENSP00000360107	chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	0.803
CLCN2	GABRA1	ENSP00000265593	ENSP00000023897	chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport	gamma-aminobutyric acid (GABA) A receptor, alpha 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.812
CLCN2	GABRD	ENSP00000265593	ENSP00000367848	chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.811
EFHC1	ARL13B	ENSP00000360107	ENSP00000377769	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	ADP-ribosylation factor-like 13B	0.621
EFHC1	BRD2	ENSP00000360107	ENSP00000378702	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	bromodomain containing 2	0.688
EFHC1	CACNA1E	ENSP00000360107	ENSP00000356545	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...]	0.886
EFHC1	CACNB4	ENSP00000360107	ENSP00000438949	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting	0.689
EFHC1	CLCN2	ENSP00000360107	ENSP00000265593	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport	0.803
EFHC1	GABRA1	ENSP00000360107	ENSP00000023897	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	gamma-aminobutyric acid (GABA) A receptor, alpha 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.628
EFHC1	GABRD	ENSP00000360107	ENSP00000367848	EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.606

page 1 of 2

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About