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STRINGSTRING
HNF1B HNF1B CYS1 CYS1 CAMLG CAMLG PKD1 PKD1 PKHD1 PKHD1 PRKD1 PRKD1 PKD2 PKD2 NEK9 NEK9 PKD2L1 PKD2L1 NEK8 NEK8 INVS INVS
"PKHD1" - polycystic kidney and hepatic disease 1 (autosomal recessive) in Homo sapiens
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protein of unknown 3D structure
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PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive); May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. May be a receptor protein that acts in collecting-duct and biliary differentiation (4074 aa)    
Predicted Functional Partners:
CAMLG
calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B (296 aa)
        score_image   score_image   0.926
HNF1B
HNF1 homeobox B; Transcription factor, probably binds to the inverted palindrome 5’-GTTAATNATTAAC-3’ (557 aa)
            score_image   0.918
PKD2
polycystic kidney disease 2 (autosomal dominant); Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intrac [...] (968 aa)
            score_image   0.903
PKD1
polycystic kidney disease 1 (autosomal dominant); Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By si [...] (4303 aa)
            score_image   0.871
PRKD1
protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...] (912 aa)
            score_image   0.757
INVS
inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be str [...] (1065 aa)
            score_image   0.729
PKD2L1
polycystic kidney disease 2-like 1; May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling (805 aa)
            score_image   0.728
NEK9
NIMA-related kinase 9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (979 aa)
            score_image   0.697
NEK8
NIMA-related kinase 8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity) (692 aa)
            score_image   0.688
CYS1
cystin 1 (158 aa)
            score_image   0.651
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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