node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMOT | INADL | ENSP00000361027 | ENSP00000360200 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | InaD-like (Drosophila) | 0.942 |
AMOT | MPP5 | ENSP00000361027 | ENSP00000261681 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | 0.998 |
ASIC3 | INADL | ENSP00000297512 | ENSP00000360200 | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | InaD-like (Drosophila) | 0.953 |
CLDN1 | CRB1 | ENSP00000295522 | ENSP00000356370 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | crumbs homolog 1 (Drosophila) | 0.403 |
CLDN1 | INADL | ENSP00000295522 | ENSP00000360200 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | InaD-like (Drosophila) | 0.959 |
CLDN1 | MPP5 | ENSP00000295522 | ENSP00000261681 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | 0.438 |
CLDN1 | TJP3 | ENSP00000295522 | ENSP00000262968 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | tight junction protein 3 | 0.976 |
CRB1 | CLDN1 | ENSP00000356370 | ENSP00000295522 | crumbs homolog 1 (Drosophila) | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.403 |
CRB1 | CRB2 | ENSP00000356370 | ENSP00000362734 | crumbs homolog 1 (Drosophila) | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | 0.826 |
CRB1 | CRB3 | ENSP00000356370 | ENSP00000349204 | crumbs homolog 1 (Drosophila) | crumbs homolog 3 (Drosophila); Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions | 0.746 |
CRB1 | INADL | ENSP00000356370 | ENSP00000360200 | crumbs homolog 1 (Drosophila) | InaD-like (Drosophila) | 0.887 |
CRB1 | MPP5 | ENSP00000356370 | ENSP00000261681 | crumbs homolog 1 (Drosophila) | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | 0.978 |
CRB1 | PARD6A | ENSP00000356370 | ENSP00000219255 | crumbs homolog 1 (Drosophila) | par-6 partitioning defective 6 homolog alpha (C. elegans); Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins | 0.453 |
CRB1 | TJP3 | ENSP00000356370 | ENSP00000262968 | crumbs homolog 1 (Drosophila) | tight junction protein 3 | 0.610 |
CRB2 | CRB1 | ENSP00000362734 | ENSP00000356370 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | crumbs homolog 1 (Drosophila) | 0.826 |
CRB2 | CRB3 | ENSP00000362734 | ENSP00000349204 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | crumbs homolog 3 (Drosophila); Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions | 0.748 |
CRB2 | INADL | ENSP00000362734 | ENSP00000360200 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | InaD-like (Drosophila) | 0.897 |
CRB2 | MPP5 | ENSP00000362734 | ENSP00000261681 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | 0.974 |
CRB2 | PARD6A | ENSP00000362734 | ENSP00000219255 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | par-6 partitioning defective 6 homolog alpha (C. elegans); Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins | 0.776 |
CRB3 | CRB1 | ENSP00000349204 | ENSP00000356370 | crumbs homolog 3 (Drosophila); Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions | crumbs homolog 1 (Drosophila) | 0.746 |