Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | OPN5 | opsin 5 (354 aa) | ||||||||||||
Predicted Functional Partners:
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 | GPR176 | G protein-coupled receptor 176; Orphan receptor (515 aa) |
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0.759 | ||||||||||
 | CCDC174 | coiled-coil domain containing 174 (467 aa) |
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0.508 | ||||||||||
 | ZNF488 | zinc finger protein 488 (340 aa) |
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0.506 | ||||||||||
 | C21orf128 | chromosome 21 open reading frame 128 (162 aa) |
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0.473 | ||||||||||
 | OPHN1 | oligophrenin 1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity). Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity) (802 aa) |
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0.466 | ||||||||||
 | NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (964 aa) |
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0.422 | ||||||||||
 | HOXC8 | homeobox C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (242 aa) |
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0.416 | ||||||||||
 | PNMAL2 | paraneoplastic Ma antigen family-like 2 (635 aa) |
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0.412 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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