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STRINGSTRING
P5CR2 P5CR2 OAT OAT PYCRL PYCRL PYCR1 PYCR1 ALDH18A1 ALDH18A1 CAD CAD ALDH4A1 ALDH4A1 UBC UBC GLUD1 GLUD1 NAGS NAGS GLUD2 GLUD2
"ALDH18A1" - aldehyde dehydrogenase 18 family, member A1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALDH18A1aldehyde dehydrogenase 18 family, member A1 (795 aa)    
Predicted Functional Partners:
PYCR1
pyrroline-5-carboxylate reductase 1; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress (319 aa)
score_image   score_image score_image   score_image score_image   0.998
P5CR2
Uncharacterized protein (359 aa)
score_image   score_image score_image   score_image score_image   0.993
PYCRL
pyrroline-5-carboxylate reductase-like (286 aa)
score_image   score_image score_image   score_image score_image   0.993
OAT
ornithine aminotransferase (439 aa)
score_image     score_image score_image   score_image   0.991
ALDH4A1
aldehyde dehydrogenase 4 family, member A1 (563 aa)
          score_image score_image   0.979
NAGS
N-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity (534 aa)
score_image         score_image score_image   0.969
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
score_image     score_image score_image score_image score_image   0.964
GLUD2
glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission (558 aa)
          score_image score_image   0.952
GLUD1
glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) (558 aa)
          score_image score_image   0.952
UBC
ubiquitin C (685 aa)
        score_image       0.952
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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