| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATIC | CLK2 | ENSP00000236959 | ENSP00000354856 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | CDC-like kinase 2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B there [...] | 0.513 |
| ATIC | PRKAA2 | ENSP00000236959 | ENSP00000360290 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | protein kinase, AMP-activated, alpha 2 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] | 0.658 |
| ATIC | TACSTD2 | ENSP00000236959 | ENSP00000360269 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.510 |
| C1QBP | TACSTD2 | ENSP00000225698 | ENSP00000360269 | complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...] | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.608 |
| CLDN1 | TACSTD2 | ENSP00000295522 | ENSP00000360269 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.593 |
| CLDN1 | TJP1 | ENSP00000295522 | ENSP00000281537 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.979 |
| CLDN7 | TACSTD2 | ENSP00000353475 | ENSP00000360269 | claudin 7; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.686 |
| CLDN7 | TJP1 | ENSP00000353475 | ENSP00000281537 | claudin 7; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.887 |
| CLK2 | ATIC | ENSP00000354856 | ENSP00000236959 | CDC-like kinase 2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B there [...] | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | 0.513 |
| CLK2 | TACSTD2 | ENSP00000354856 | ENSP00000360269 | CDC-like kinase 2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B there [...] | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.757 |
| ERVW-1 | LMLN | ENSP00000419945 | ENSP00000410926 | endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis | leishmanolysin-like (metallopeptidase M8 family); Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration (By similarity) | 0.580 |
| ERVW-1 | TACSTD2 | ENSP00000419945 | ENSP00000360269 | endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.519 |
| KIAA1109 | TACSTD2 | ENSP00000264501 | ENSP00000360269 | KIAA1109 | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.682 |
| LMLN | ERVW-1 | ENSP00000410926 | ENSP00000419945 | leishmanolysin-like (metallopeptidase M8 family); Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration (By similarity) | endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis | 0.580 |
| LMLN | TACSTD2 | ENSP00000410926 | ENSP00000360269 | leishmanolysin-like (metallopeptidase M8 family); Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration (By similarity) | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.728 |
| PRKAA2 | ATIC | ENSP00000360290 | ENSP00000236959 | protein kinase, AMP-activated, alpha 2 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | 0.658 |
| PRKAA2 | TACSTD2 | ENSP00000360290 | ENSP00000360269 | protein kinase, AMP-activated, alpha 2 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 0.587 |
| TACSTD2 | ATIC | ENSP00000360269 | ENSP00000236959 | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | 0.510 |
| TACSTD2 | C1QBP | ENSP00000360269 | ENSP00000225698 | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...] | 0.608 |
| TACSTD2 | CLDN1 | ENSP00000360269 | ENSP00000295522 | tumor-associated calcium signal transducer 2; May function as a growth factor receptor | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.593 |
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