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STRINGSTRING
LIPA LIPA SOAT1 SOAT1 DHCR7 DHCR7 DHCR24 DHCR24 TP53 TP53 UBC UBC SC5DL SC5DL CYP51A1 CYP51A1 LSS LSS MSMO1 MSMO1 TM7SF2 TM7SF2
"DHCR24" - 24-dehydrocholesterol reductase in Homo sapiens
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protein of unknown 3D structure
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DHCR2424-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (516 aa)    
Predicted Functional Partners:
SC5DL
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol (299 aa)
      score_image   score_image score_image   0.984
DHCR7
7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) (475 aa)
      score_image   score_image score_image   0.984
TM7SF2
transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol (418 aa)
      score_image   score_image score_image   0.972
LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (732 aa)
      score_image   score_image score_image   0.954
MSMO1
methylsterol monooxygenase 1 (293 aa)
      score_image   score_image score_image   0.953
CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1 (509 aa)
      score_image   score_image score_image   0.949
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.931
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (393 aa)
        score_image   score_image   0.928
SOAT1
sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase (550 aa)
          score_image score_image   0.921
LIPA
lipase A, lysosomal acid, cholesterol esterase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation (399 aa)
          score_image score_image   0.919
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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