node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | DHCR24 | ENSP00000003100 | ENSP00000360316 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | 0.949 |
CYP51A1 | DHCR7 | ENSP00000003100 | ENSP00000347717 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | 0.861 |
CYP51A1 | LSS | ENSP00000003100 | ENSP00000348762 | cytochrome P450, family 51, subfamily A, polypeptide 1 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.999 |
CYP51A1 | MSMO1 | ENSP00000003100 | ENSP00000261507 | cytochrome P450, family 51, subfamily A, polypeptide 1 | methylsterol monooxygenase 1 | 0.997 |
CYP51A1 | SC5DL | ENSP00000003100 | ENSP00000264027 | cytochrome P450, family 51, subfamily A, polypeptide 1 | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.993 |
CYP51A1 | TM7SF2 | ENSP00000003100 | ENSP00000279263 | cytochrome P450, family 51, subfamily A, polypeptide 1 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.994 |
CYP51A1 | UBC | ENSP00000003100 | ENSP00000344818 | cytochrome P450, family 51, subfamily A, polypeptide 1 | ubiquitin C | 0.986 |
DHCR24 | CYP51A1 | ENSP00000360316 | ENSP00000003100 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.949 |
DHCR24 | DHCR7 | ENSP00000360316 | ENSP00000347717 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | 0.984 |
DHCR24 | LIPA | ENSP00000360316 | ENSP00000337354 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | lipase A, lysosomal acid, cholesterol esterase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation | 0.919 |
DHCR24 | LSS | ENSP00000360316 | ENSP00000348762 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.954 |
DHCR24 | MSMO1 | ENSP00000360316 | ENSP00000261507 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | methylsterol monooxygenase 1 | 0.953 |
DHCR24 | SC5DL | ENSP00000360316 | ENSP00000264027 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.984 |
DHCR24 | SOAT1 | ENSP00000360316 | ENSP00000356591 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase | 0.921 |
DHCR24 | TM7SF2 | ENSP00000360316 | ENSP00000279263 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.972 |
DHCR24 | TP53 | ENSP00000360316 | ENSP00000269305 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.928 |
DHCR24 | UBC | ENSP00000360316 | ENSP00000344818 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | ubiquitin C | 0.931 |
DHCR7 | CYP51A1 | ENSP00000347717 | ENSP00000003100 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.861 |
DHCR7 | DHCR24 | ENSP00000347717 | ENSP00000360316 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | 0.984 |
DHCR7 | LIPA | ENSP00000347717 | ENSP00000337354 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | lipase A, lysosomal acid, cholesterol esterase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation | 0.933 |