node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNT2 | SSBP3 | ENSP00000307479 | ENSP00000360371 | aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) | single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region (By similarity) | 0.530 |
CBFA2T2 | SSBP3 | ENSP00000262653 | ENSP00000360371 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region (By similarity) | 0.525 |
CBFA2T2 | TAL1 | ENSP00000262653 | ENSP00000294339 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | T-cell acute lymphocytic leukemia 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) | 0.661 |
IL36RN | SSBP3 | ENSP00000259212 | ENSP00000360371 | interleukin 36 receptor antagonist; Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL- 1R1), that is present in epithelial barriers and takes part in local inflammatory response | single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region (By similarity) | 0.597 |
LDB1 | LHX1 | ENSP00000392466 | ENSP00000254457 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | 0.897 |
LDB1 | LHX5 | ENSP00000392466 | ENSP00000261731 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system | 0.797 |
LDB1 | LMO3 | ENSP00000392466 | ENSP00000312856 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | LIM domain only 3 (rhombotin-like 2) | 0.904 |
LDB1 | SSBP3 | ENSP00000392466 | ENSP00000360371 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region (By similarity) | 0.950 |
LDB1 | TAL1 | ENSP00000392466 | ENSP00000294339 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | T-cell acute lymphocytic leukemia 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) | 0.998 |
LDB2 | LHX1 | ENSP00000306772 | ENSP00000254457 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | 0.824 |
LDB2 | LHX5 | ENSP00000306772 | ENSP00000261731 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system | 0.788 |
LDB2 | LMO3 | ENSP00000306772 | ENSP00000312856 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | LIM domain only 3 (rhombotin-like 2) | 0.944 |
LDB2 | SSBP3 | ENSP00000306772 | ENSP00000360371 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region (By similarity) | 0.888 |
LDB2 | TAL1 | ENSP00000306772 | ENSP00000294339 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | T-cell acute lymphocytic leukemia 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) | 0.946 |
LHX1 | LDB1 | ENSP00000254457 | ENSP00000392466 | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | 0.897 |
LHX1 | LDB2 | ENSP00000254457 | ENSP00000306772 | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | 0.824 |
LHX1 | SSBP3 | ENSP00000254457 | ENSP00000360371 | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region (By similarity) | 0.654 |
LHX5 | LDB1 | ENSP00000261731 | ENSP00000392466 | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | 0.797 |
LHX5 | LDB2 | ENSP00000261731 | ENSP00000306772 | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | 0.788 |
LHX5 | SSBP3 | ENSP00000261731 | ENSP00000360371 | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system | single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region (By similarity) | 0.508 |