Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MRPL41 | mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa) | ||||||||||||
Predicted Functional Partners:
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 | MRPL47 | mitochondrial ribosomal protein L47 (250 aa) |
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0.954 | ||||||||
 | MRPL19 | mitochondrial ribosomal protein L19 (292 aa) |
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0.954 | ||||||||
 | MRPL27 | mitochondrial ribosomal protein L27 (148 aa) |
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0.953 | ||||||||
 | MRPS2 | mitochondrial ribosomal protein S2 (296 aa) |
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0.949 | ||||||||
 | MRPL23 | mitochondrial ribosomal protein L23 (153 aa) |
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0.914 | ||||||||
 | MRPL46 | mitochondrial ribosomal protein L46 (279 aa) |
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0.899 | |||||||||
 | MRPL15 | mitochondrial ribosomal protein L15 (296 aa) |
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0.898 | ||||||||
 | MRPL1 | mitochondrial ribosomal protein L1 (325 aa) |
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0.869 | ||||||||
 | MRPL13 | mitochondrial ribosomal protein L13 (178 aa) |
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0.861 | ||||||||
 | MRPL32 | mitochondrial ribosomal protein L32 (188 aa) |
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0.835 | ||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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