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GUCY2D GUCY2D ADCY5 ADCY5 CNGB3 CNGB3 ADCY4 ADCY4 PDE6C PDE6C CNGA3 CNGA3 ADCY2 ADCY2 PDE6H PDE6H GNAT2 GNAT2 ADCY6 ADCY6 GUCY2F GUCY2F
"PDE6C" - phosphodiesterase 6C, cGMP-specific, cone, alpha prime in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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Score
PDE6Cphosphodiesterase 6C, cGMP-specific, cone, alpha prime (858 aa)    
Predicted Functional Partners:
CNGB3
cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] (809 aa)
          score_image score_image   0.986
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase (354 aa)
      score_image score_image score_image score_image   0.983
CNGA3
cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] (694 aa)
          score_image score_image   0.981
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (83 aa)
      score_image score_image score_image score_image   0.965
GUCY2F
guanylate cyclase 2F, retinal; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction (1108 aa)
      score_image score_image score_image score_image   0.965
GUCY2D
guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction (1103 aa)
      score_image score_image score_image score_image   0.964
ADCY5
adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1261 aa)
      score_image score_image score_image score_image   0.962
ADCY2
adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (1091 aa)
      score_image score_image score_image score_image   0.962
ADCY4
adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity) (1077 aa)
      score_image score_image score_image score_image   0.962
ADCY6
adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) (1168 aa)
      score_image score_image score_image score_image   0.962
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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