| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACADL | ACADM | ENSP00000233710 | ENSP00000409612 | acyl-CoA dehydrogenase, long chain | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | 0.934 |
| ACADL | ACOX1 | ENSP00000233710 | ENSP00000293217 | acyl-CoA dehydrogenase, long chain | acyl-CoA oxidase 1, palmitoyl | 0.588 |
| ACADL | CPT1A | ENSP00000233710 | ENSP00000265641 | acyl-CoA dehydrogenase, long chain | carnitine palmitoyltransferase 1A (liver); Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism | 0.507 |
| ACADL | CPT2 | ENSP00000233710 | ENSP00000360541 | acyl-CoA dehydrogenase, long chain | carnitine palmitoyltransferase 2 | 0.950 |
| ACADL | PPARA | ENSP00000233710 | ENSP00000262735 | acyl-CoA dehydrogenase, long chain | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | 0.418 |
| ACADL | SLC25A20 | ENSP00000233710 | ENSP00000326305 | acyl-CoA dehydrogenase, long chain | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway | 0.440 |
| ACADM | ACADL | ENSP00000409612 | ENSP00000233710 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | acyl-CoA dehydrogenase, long chain | 0.934 |
| ACADM | ACOX1 | ENSP00000409612 | ENSP00000293217 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | acyl-CoA oxidase 1, palmitoyl | 0.643 |
| ACADM | ACOX3 | ENSP00000409612 | ENSP00000348775 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | 0.525 |
| ACADM | CPT1A | ENSP00000409612 | ENSP00000265641 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | carnitine palmitoyltransferase 1A (liver); Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism | 0.629 |
| ACADM | CPT1B | ENSP00000409612 | ENSP00000312189 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | carnitine palmitoyltransferase 1B (muscle) | 0.546 |
| ACADM | CPT2 | ENSP00000409612 | ENSP00000360541 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | carnitine palmitoyltransferase 2 | 0.959 |
| ACADM | PPARA | ENSP00000409612 | ENSP00000262735 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | 0.950 |
| ACADM | SLC25A20 | ENSP00000409612 | ENSP00000326305 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway | 0.522 |
| ACADVL | ACOX1 | ENSP00000349297 | ENSP00000293217 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | acyl-CoA oxidase 1, palmitoyl | 0.555 |
| ACADVL | CPT1A | ENSP00000349297 | ENSP00000265641 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | carnitine palmitoyltransferase 1A (liver); Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism | 0.628 |
| ACADVL | CPT1B | ENSP00000349297 | ENSP00000312189 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | carnitine palmitoyltransferase 1B (muscle) | 0.558 |
| ACADVL | CPT2 | ENSP00000349297 | ENSP00000360541 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | carnitine palmitoyltransferase 2 | 0.971 |
| ACADVL | PPARA | ENSP00000349297 | ENSP00000262735 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | 0.469 |
| ACADVL | SLC25A20 | ENSP00000349297 | ENSP00000326305 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway | 0.570 |
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