node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DPP4 | DPP7 | ENSP00000353731 | ENSP00000360635 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | 0.722 |
DPP4 | DPP8 | ENSP00000353731 | ENSP00000339208 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | dipeptidyl-peptidase 8 | 0.439 |
DPP4 | DPP9 | ENSP00000353731 | ENSP00000262960 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | dipeptidyl-peptidase 9 | 0.451 |
DPP4 | FAP | ENSP00000353731 | ENSP00000188790 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | fibroblast activation protein, alpha; In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers | 0.600 |
DPP7 | DPP4 | ENSP00000360635 | ENSP00000353731 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | 0.722 |
DPP7 | DPP8 | ENSP00000360635 | ENSP00000339208 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | dipeptidyl-peptidase 8 | 0.791 |
DPP7 | DPP9 | ENSP00000360635 | ENSP00000262960 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | dipeptidyl-peptidase 9 | 0.836 |
DPP7 | FAP | ENSP00000360635 | ENSP00000188790 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | fibroblast activation protein, alpha; In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers | 0.701 |
DPP7 | MYCBP | ENSP00000360635 | ENSP00000380702 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | c-myc binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | 0.644 |
DPP7 | SDHD | ENSP00000360635 | ENSP00000364699 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | succinate dehydrogenase complex, subunit D, integral membrane protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity) | 0.661 |
DPP7 | TIMM8A | ENSP00000360635 | ENSP00000361993 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | translocase of inner mitochondrial membrane 8 homolog A (yeast); Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins [...] | 0.751 |
DPP7 | TIMM8B | ENSP00000360635 | ENSP00000438455 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | translocase of inner mitochondrial membrane 8 homolog B (yeast); Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity) | 0.758 |
DPP7 | TP53 | ENSP00000360635 | ENSP00000269305 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.800 |
DPP7 | UBC | ENSP00000360635 | ENSP00000344818 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | ubiquitin C | 0.802 |
DPP8 | DPP4 | ENSP00000339208 | ENSP00000353731 | dipeptidyl-peptidase 8 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | 0.439 |
DPP8 | DPP7 | ENSP00000339208 | ENSP00000360635 | dipeptidyl-peptidase 8 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | 0.791 |
DPP8 | FAP | ENSP00000339208 | ENSP00000188790 | dipeptidyl-peptidase 8 | fibroblast activation protein, alpha; In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers | 0.425 |
DPP8 | UBC | ENSP00000339208 | ENSP00000344818 | dipeptidyl-peptidase 8 | ubiquitin C | 0.644 |
DPP9 | DPP4 | ENSP00000262960 | ENSP00000353731 | dipeptidyl-peptidase 9 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | 0.451 |
DPP9 | DPP7 | ENSP00000262960 | ENSP00000360635 | dipeptidyl-peptidase 9 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | 0.836 |