node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTF3L4 | ENSG00000257529 | ENSP00000360664 | ENSP00000386655 | basic transcription factor 3-like 4 | Uncharacterized protein | 0.882 |
BTF3L4 | NACA | ENSP00000360664 | ENSP00000448035 | basic transcription factor 3-like 4 | nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...] | 0.974 |
BTF3L4 | NACA2 | ENSP00000360664 | ENSP00000427802 | basic transcription factor 3-like 4 | nascent polypeptide-associated complex alpha subunit 2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene [...] | 0.990 |
BTF3L4 | NACAD | ENSP00000360664 | ENSP00000420477 | basic transcription factor 3-like 4 | NAC alpha domain containing; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity) | 0.974 |
BTF3L4 | PRKAA1 | ENSP00000360664 | ENSP00000346148 | basic transcription factor 3-like 4 | protein kinase, AMP-activated, alpha 1 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] | 0.858 |
BTF3L4 | PRKAA2 | ENSP00000360664 | ENSP00000360290 | basic transcription factor 3-like 4 | protein kinase, AMP-activated, alpha 2 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] | 0.858 |
BTF3L4 | RPL23A | ENSP00000360664 | ENSP00000389103 | basic transcription factor 3-like 4 | ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity) | 0.967 |
BTF3L4 | RPL36A | ENSP00000360664 | ENSP00000404375 | basic transcription factor 3-like 4 | ribosomal protein L36a | 0.882 |
BTF3L4 | RPL36AL | ENSP00000360664 | ENSP00000346012 | basic transcription factor 3-like 4 | ribosomal protein L36a-like | 0.882 |
BTF3L4 | UBC | ENSP00000360664 | ENSP00000344818 | basic transcription factor 3-like 4 | ubiquitin C | 0.868 |
ENSG00000257529 | BTF3L4 | ENSP00000386655 | ENSP00000360664 | Uncharacterized protein | basic transcription factor 3-like 4 | 0.882 |
ENSG00000257529 | NACA | ENSP00000386655 | ENSP00000448035 | Uncharacterized protein | nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...] | 0.734 |
ENSG00000257529 | NACA2 | ENSP00000386655 | ENSP00000427802 | Uncharacterized protein | nascent polypeptide-associated complex alpha subunit 2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene [...] | 0.734 |
ENSG00000257529 | NACAD | ENSP00000386655 | ENSP00000420477 | Uncharacterized protein | NAC alpha domain containing; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity) | 0.734 |
ENSG00000257529 | RPL23A | ENSP00000386655 | ENSP00000389103 | Uncharacterized protein | ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity) | 0.959 |
ENSG00000257529 | UBC | ENSP00000386655 | ENSP00000344818 | Uncharacterized protein | ubiquitin C | 0.479 |
NACA | BTF3L4 | ENSP00000448035 | ENSP00000360664 | nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...] | basic transcription factor 3-like 4 | 0.974 |
NACA | ENSG00000257529 | ENSP00000448035 | ENSP00000386655 | nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...] | Uncharacterized protein | 0.734 |
NACA | NACA2 | ENSP00000448035 | ENSP00000427802 | nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...] | nascent polypeptide-associated complex alpha subunit 2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene [...] | 0.876 |
NACA | PRKAA1 | ENSP00000448035 | ENSP00000346148 | nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...] | protein kinase, AMP-activated, alpha 1 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] | 0.682 |