node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGFG1 | RAB3B | ENSP00000387282 | ENSP00000360718 | ArfGAP with FG repeats 1 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.663 |
AGFG1 | RPH3A | ENSP00000387282 | ENSP00000374036 | ArfGAP with FG repeats 1 | rabphilin 3A homolog (mouse); Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity) | 0.499 |
AGFG1 | UBC | ENSP00000387282 | ENSP00000344818 | ArfGAP with FG repeats 1 | ubiquitin C | 0.739 |
DOC2B | RAB3B | ENSP00000343665 | ENSP00000360718 | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.793 |
PIGR | RAB3B | ENSP00000348888 | ENSP00000360718 | polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.982 |
RAB35 | RAB3B | ENSP00000229340 | ENSP00000360718 | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.688 |
RAB35 | UBC | ENSP00000229340 | ENSP00000344818 | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | ubiquitin C | 0.961 |
RAB3B | AGFG1 | ENSP00000360718 | ENSP00000387282 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | ArfGAP with FG repeats 1 | 0.663 |
RAB3B | DOC2B | ENSP00000360718 | ENSP00000343665 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | 0.793 |
RAB3B | PIGR | ENSP00000360718 | ENSP00000348888 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment | 0.982 |
RAB3B | RAB35 | ENSP00000360718 | ENSP00000229340 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | 0.688 |
RAB3B | RIMS2 | ENSP00000360718 | ENSP00000384892 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | 0.727 |
RAB3B | RPH3A | ENSP00000360718 | ENSP00000374036 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | rabphilin 3A homolog (mouse); Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity) | 0.976 |
RAB3B | RPH3AL | ENSP00000360718 | ENSP00000328977 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | rabphilin 3A-like (without C2 domains); Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells | 0.835 |
RAB3B | SYT1 | ENSP00000360718 | ENSP00000261205 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.696 |
RAB3B | TJP2 | ENSP00000360718 | ENSP00000438262 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | tight junction protein 2 | 0.747 |
RAB3B | UBC | ENSP00000360718 | ENSP00000344818 | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | ubiquitin C | 0.798 |
RIMS2 | RAB3B | ENSP00000384892 | ENSP00000360718 | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.727 |
RIMS2 | RPH3AL | ENSP00000384892 | ENSP00000328977 | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | rabphilin 3A-like (without C2 domains); Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells | 0.633 |
RPH3A | AGFG1 | ENSP00000374036 | ENSP00000387282 | rabphilin 3A homolog (mouse); Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity) | ArfGAP with FG repeats 1 | 0.499 |