Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | RABL6 | RAB, member RAS oncogene family-like 6 (730 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | STX5 | syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) (355 aa) |
 |
|
0.906 | |||||||||
 | RABGGTB | Rab geranylgeranyltransferase, beta subunit; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively (331 aa) |
|
|
0.891 | |||||||||
 | YIPF7 | Yip1 domain family, member 7 (280 aa) |
|
|
0.876 | |||||||||
 | YIPF5 | Yip1 domain family, member 5; Plays a role in transport between endoplasmic reticulum and Golgi (257 aa) |
|
|
0.876 | |||||||||
 | SPINK7 | serine peptidase inhibitor, Kazal type 7 (putative); Probable serine protease inhibitor (85 aa) |
|
|
0.848 | |||||||||
 | SCFD1 | sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) (642 aa) |
|
|
0.806 | |||||||||
 | RABIF | RAB interacting factor; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (123 aa) |
|
|
0.782 | |||||||||
 | STX18 | syntaxin 18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (335 aa) |
|
|
0.762 | |||||||||
 | TBRG1 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability (411 aa) |
|
0.753 | ||||||||||
 | BET1L | blocked early in transport 1 homolog (S. cerevisiae)-like; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity) (111 aa) |
|
|
0.727 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
