| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADORA1 | NOS3 | ENSP00000308549 | ENSP00000297494 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.480 |
| ADORA1 | SLC1A2 | ENSP00000308549 | ENSP00000278379 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | solute carrier family 1 (glial high affinity glutamate transporter), member 2; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | 0.834 |
| ADORA1 | SLC29A1 | ENSP00000308549 | ENSP00000360773 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | solute carrier family 29 (nucleoside transporters), member 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) | 0.754 |
| DCK | SLC28A1 | ENSP00000286648 | ENSP00000286749 | deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents | solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3’-azido-3’-deoxythymidine (AZT) and 2’,3’-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective i [...] | 0.658 |
| DCK | SLC28A2 | ENSP00000286648 | ENSP00000315006 | deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues | 0.569 |
| DCK | SLC28A3 | ENSP00000286648 | ENSP00000365413 | deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents | solute carrier family 28 (sodium-coupled nucleoside transporter), member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2-1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3’-azido-3’-deoxythymidine (AZT), ribavirin and 3-deazauridine | 0.660 |
| DCK | SLC29A1 | ENSP00000286648 | ENSP00000360773 | deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents | solute carrier family 29 (nucleoside transporters), member 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) | 0.811 |
| DCK | UBC | ENSP00000286648 | ENSP00000344818 | deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents | ubiquitin C | 0.818 |
| NOS3 | ADORA1 | ENSP00000297494 | ENSP00000308549 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | 0.480 |
| NOS3 | SLC29A1 | ENSP00000297494 | ENSP00000360773 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | solute carrier family 29 (nucleoside transporters), member 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) | 0.821 |
| NOS3 | TGFB1 | ENSP00000297494 | ENSP00000221930 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.903 |
| NOS3 | UBC | ENSP00000297494 | ENSP00000344818 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | ubiquitin C | 0.617 |
| SLC1A2 | ADORA1 | ENSP00000278379 | ENSP00000308549 | solute carrier family 1 (glial high affinity glutamate transporter), member 2; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | 0.834 |
| SLC1A2 | SLC29A1 | ENSP00000278379 | ENSP00000360773 | solute carrier family 1 (glial high affinity glutamate transporter), member 2; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | solute carrier family 29 (nucleoside transporters), member 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) | 0.836 |
| SLC28A1 | DCK | ENSP00000286749 | ENSP00000286648 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3’-azido-3’-deoxythymidine (AZT) and 2’,3’-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective i [...] | deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents | 0.658 |
| SLC28A1 | SLC29A1 | ENSP00000286749 | ENSP00000360773 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3’-azido-3’-deoxythymidine (AZT) and 2’,3’-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective i [...] | solute carrier family 29 (nucleoside transporters), member 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) | 0.894 |
| SLC28A1 | UPF2 | ENSP00000286749 | ENSP00000348708 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3’-azido-3’-deoxythymidine (AZT) and 2’,3’-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective i [...] | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.507 |
| SLC28A2 | DCK | ENSP00000315006 | ENSP00000286648 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues | deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents | 0.569 |
| SLC28A2 | SLC29A1 | ENSP00000315006 | ENSP00000360773 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues | solute carrier family 29 (nucleoside transporters), member 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) | 0.894 |
| SLC28A2 | UPF2 | ENSP00000315006 | ENSP00000348708 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.570 |
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