SARDH protein (Homo sapiens) - STRING network view

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SARDH

sarcosine dehydrogenase (918 aa)

Predicted Functional Partners:

GLDC

0.999

GCSH

0.994

SHMT1

0.981

SHMT2

0.979

AGXT

0.929

DAO

0.927

DMGDH

0.924

GATM

0.917

ALAS2

0.911

AGXT2

0.909

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT	AGXT2	ENSP00000302620	ENSP00000231420	alanine-glyoxylate aminotransferase	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	0.988
AGXT	ALAS2	ENSP00000302620	ENSP00000332369	alanine-glyoxylate aminotransferase	aminolevulinate, delta-, synthase 2	0.906
AGXT	DAO	ENSP00000302620	ENSP00000228476	alanine-glyoxylate aminotransferase	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids	0.931
AGXT	DMGDH	ENSP00000302620	ENSP00000255189	alanine-glyoxylate aminotransferase	dimethylglycine dehydrogenase	0.415
AGXT	GATM	ENSP00000302620	ENSP00000379895	alanine-glyoxylate aminotransferase	glycine amidinotransferase (L-arginine-glycine amidinotransferase); Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis	0.918
AGXT	GCSH	ENSP00000302620	ENSP00000319531	alanine-glyoxylate aminotransferase	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.913
AGXT	GLDC	ENSP00000302620	ENSP00000370737	alanine-glyoxylate aminotransferase	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.965
AGXT	SARDH	ENSP00000302620	ENSP00000360938	alanine-glyoxylate aminotransferase	sarcosine dehydrogenase	0.929
AGXT	SHMT1	ENSP00000302620	ENSP00000318868	alanine-glyoxylate aminotransferase	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.963
AGXT	SHMT2	ENSP00000302620	ENSP00000333667	alanine-glyoxylate aminotransferase	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.961
AGXT2	AGXT	ENSP00000231420	ENSP00000302620	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	alanine-glyoxylate aminotransferase	0.988
AGXT2	ALAS2	ENSP00000231420	ENSP00000332369	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	aminolevulinate, delta-, synthase 2	0.905
AGXT2	DAO	ENSP00000231420	ENSP00000228476	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids	0.825
AGXT2	GATM	ENSP00000231420	ENSP00000379895	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	glycine amidinotransferase (L-arginine-glycine amidinotransferase); Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis	0.918
AGXT2	GLDC	ENSP00000231420	ENSP00000370737	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.953
AGXT2	SARDH	ENSP00000231420	ENSP00000360938	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	sarcosine dehydrogenase	0.909
AGXT2	SHMT1	ENSP00000231420	ENSP00000318868	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.900
AGXT2	SHMT2	ENSP00000231420	ENSP00000333667	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.913
ALAS2	AGXT	ENSP00000332369	ENSP00000302620	aminolevulinate, delta-, synthase 2	alanine-glyoxylate aminotransferase	0.906
ALAS2	AGXT2	ENSP00000332369	ENSP00000231420	aminolevulinate, delta-, synthase 2	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	0.905

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