node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPM | CDK5RAP2 | ENSP00000356379 | ENSP00000343818 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | CDK5 regulatory subunit associated protein 2 | 0.779 |
ASPM | CENPJ | ENSP00000356379 | ENSP00000371308 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | 0.770 |
ASPM | CEP152 | ENSP00000356379 | ENSP00000382271 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | centrosomal protein 152kDa; Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation | 0.761 |
ASPM | CEP63 | ENSP00000356379 | ENSP00000336524 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | centrosomal protein 63kDa; Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity) | 0.822 |
ASPM | MCPH1 | ENSP00000356379 | ENSP00000342924 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | microcephalin 1; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex | 0.835 |
ASPM | STIL | ENSP00000356379 | ENSP00000360944 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | SCL/TAL1 interrupting locus; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 | 0.759 |
ASPM | WDR62 | ENSP00000356379 | ENSP00000384792 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | WD repeat domain 62; Required for cerebral cortical development. Plays a role in neuronal proliferation and migration | 0.750 |
CDK5RAP2 | ASPM | ENSP00000343818 | ENSP00000356379 | CDK5 regulatory subunit associated protein 2 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.779 |
CDK5RAP2 | CENPJ | ENSP00000343818 | ENSP00000371308 | CDK5 regulatory subunit associated protein 2 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | 0.982 |
CDK5RAP2 | CEP152 | ENSP00000343818 | ENSP00000382271 | CDK5 regulatory subunit associated protein 2 | centrosomal protein 152kDa; Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation | 0.976 |
CDK5RAP2 | CEP63 | ENSP00000343818 | ENSP00000336524 | CDK5 regulatory subunit associated protein 2 | centrosomal protein 63kDa; Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity) | 0.973 |
CDK5RAP2 | MCPH1 | ENSP00000343818 | ENSP00000342924 | CDK5 regulatory subunit associated protein 2 | microcephalin 1; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex | 0.770 |
CDK5RAP2 | STIL | ENSP00000343818 | ENSP00000360944 | CDK5 regulatory subunit associated protein 2 | SCL/TAL1 interrupting locus; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 | 0.749 |
CDK5RAP2 | WDR62 | ENSP00000343818 | ENSP00000384792 | CDK5 regulatory subunit associated protein 2 | WD repeat domain 62; Required for cerebral cortical development. Plays a role in neuronal proliferation and migration | 0.753 |
CENPJ | ASPM | ENSP00000371308 | ENSP00000356379 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.770 |
CENPJ | CDK5RAP2 | ENSP00000371308 | ENSP00000343818 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | CDK5 regulatory subunit associated protein 2 | 0.982 |
CENPJ | CEP152 | ENSP00000371308 | ENSP00000382271 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | centrosomal protein 152kDa; Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation | 0.990 |
CENPJ | CEP63 | ENSP00000371308 | ENSP00000336524 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | centrosomal protein 63kDa; Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity) | 0.974 |
CENPJ | MCPH1 | ENSP00000371308 | ENSP00000342924 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | microcephalin 1; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex | 0.707 |
CENPJ | SASS6 | ENSP00000371308 | ENSP00000287482 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers | 0.997 |