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STRINGSTRING
SASS6 SASS6 WDR62 WDR62 MCPH1 MCPH1 PTCH1 PTCH1 CENPJ CENPJ CEP152 CEP152 STIL STIL SHH SHH CDK5RAP2 CDK5RAP2 CEP63 CEP63 ASPM ASPM
"STIL" - SCL/TAL1 interrupting locus in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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STILSCL/TAL1 interrupting locus; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (1288 aa)    
Predicted Functional Partners:
SHH
sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] (462 aa)
          score_image score_image   0.982
CENPJ
centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome (1338 aa)
      score_image score_image   score_image   0.952
PTCH1
patched 1 (1447 aa)
          score_image score_image   0.905
CEP63
centrosomal protein 63kDa; Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity) (703 aa)
            score_image   0.862
CEP152
centrosomal protein 152kDa; Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation (1654 aa)
      score_image     score_image   0.764
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila) (3477 aa)
      score_image     score_image   0.759
CDK5RAP2
CDK5 regulatory subunit associated protein 2 (1893 aa)
            score_image   0.749
WDR62
WD repeat domain 62; Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (1523 aa)
            score_image   0.748
MCPH1
microcephalin 1; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (835 aa)
            score_image   0.740
SASS6
spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers (657 aa)
      score_image score_image   score_image   0.739
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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