| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAMKMT | PACRG | ENSP00000367755 | ENSP00000337946 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease | 0.549 |
| CAMKMT | PREPL | ENSP00000367755 | ENSP00000260648 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | prolyl endopeptidase-like | 0.881 |
| CAMKMT | SURF2 | ENSP00000367755 | ENSP00000361032 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | surfeit 2 | 0.594 |
| ERGIC1 | SURF1 | ENSP00000377374 | ENSP00000361042 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | surfeit 1; Probably involved in the biogenesis of the COX complex | 0.414 |
| ERGIC1 | SURF2 | ENSP00000377374 | ENSP00000361032 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | surfeit 2 | 0.657 |
| ERGIC1 | SURF4 | ENSP00000377374 | ENSP00000361057 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.891 |
| MED22 | SURF1 | ENSP00000342343 | ENSP00000361042 | mediator complex subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | surfeit 1; Probably involved in the biogenesis of the COX complex | 0.707 |
| MED22 | SURF2 | ENSP00000342343 | ENSP00000361032 | mediator complex subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | surfeit 2 | 0.689 |
| MED22 | SURF4 | ENSP00000342343 | ENSP00000361057 | mediator complex subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.485 |
| MED22 | SURF6 | ENSP00000342343 | ENSP00000361092 | mediator complex subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) | 0.755 |
| OXA1L | SURF1 | ENSP00000285848 | ENSP00000361042 | oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria | surfeit 1; Probably involved in the biogenesis of the COX complex | 0.714 |
| OXA1L | SURF2 | ENSP00000285848 | ENSP00000361032 | oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria | surfeit 2 | 0.564 |
| OXA1L | SURF6 | ENSP00000285848 | ENSP00000361092 | oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria | surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) | 0.562 |
| PACRG | CAMKMT | ENSP00000337946 | ENSP00000367755 | PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | 0.549 |
| PACRG | PREPL | ENSP00000337946 | ENSP00000260648 | PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease | prolyl endopeptidase-like | 0.623 |
| PACRG | SURF2 | ENSP00000337946 | ENSP00000361032 | PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease | surfeit 2 | 0.552 |
| PREPL | CAMKMT | ENSP00000260648 | ENSP00000367755 | prolyl endopeptidase-like | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | 0.881 |
| PREPL | PACRG | ENSP00000260648 | ENSP00000337946 | prolyl endopeptidase-like | PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease | 0.623 |
| PREPL | SURF2 | ENSP00000260648 | ENSP00000361032 | prolyl endopeptidase-like | surfeit 2 | 0.580 |
| SURF1 | ERGIC1 | ENSP00000361042 | ENSP00000377374 | surfeit 1; Probably involved in the biogenesis of the COX complex | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | 0.414 |
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