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STRINGSTRING
SURF2 SURF2 SCO1 SCO1 SURF4 SURF4 MT-CO2 MT-CO2 SURF1 SURF1 SCO2 SCO2 COX11 COX11 COX15 COX15 COX5A COX5A MT-CO3 MT-CO3 COX10 COX10
"SURF1" - surfeit 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SURF1surfeit 1; Probably involved in the biogenesis of the COX complex (300 aa)    
Predicted Functional Partners:
COX10
cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) (443 aa)
 score_image       score_image   score_image   0.967
SCO2
SCO2 cytochrome c oxidase assembly protein; Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2) (266 aa)
 score_image     score_image     score_image   0.916
COX15
cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A (410 aa)
 score_image     score_image score_image   score_image   0.916
SCO1
SCO1 cytochrome c oxidase assembly protein; Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX (301 aa)
 score_image     score_image     score_image   0.879
COX11
cytochrome c oxidase assembly homolog 11 (yeast); Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) (276 aa)
 score_image       score_image   score_image   0.856
SURF2
surfeit 2 (256 aa)
             score_image   0.846
MT-CO2
mitochondrially encoded cytochrome c oxidase II; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 (By similarity) (227 aa)
 score_image       score_image   score_image   0.833
MT-CO3
mitochondrially encoded cytochrome c oxidase III; Subunits I, II and III form the functional core of the enzyme complex (By similarity) (261 aa)
 score_image           score_image   0.812
COX5A
cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (150 aa)
         score_image   score_image   0.801
SURF4
surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (269 aa)
   score_image         score_image   0.799
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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