node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DAG1 | DPM3 | ENSP00000312435 | ENSP00000357384 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | 0.455 |
DAG1 | FKRP | ENSP00000312435 | ENSP00000326570 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) | 0.873 |
DAG1 | FKTN | ENSP00000312435 | ENSP00000223528 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | fukutin; May be a glycosyltransferase which participates in glycosylation of alpha-dystroglycan/DAG1. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development | 0.818 |
DAG1 | LARGE | ENSP00000312435 | ENSP00000347088 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | like-glycosyltransferase | 0.764 |
DAG1 | MGAT4C | ENSP00000312435 | ENSP00000331664 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative); Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity) | 0.908 |
DAG1 | POMGNT1 | ENSP00000312435 | ENSP00000361052 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O- Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity | 0.810 |
DAG1 | POMT1 | ENSP00000312435 | ENSP00000361302 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | protein-O-mannosyltransferase 1 | 0.949 |
DAG1 | POMT2 | ENSP00000312435 | ENSP00000261534 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | protein-O-mannosyltransferase 2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient | 0.910 |
DPM3 | DAG1 | ENSP00000357384 | ENSP00000312435 | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.455 |
DPM3 | FKRP | ENSP00000357384 | ENSP00000326570 | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) | 0.408 |
DPM3 | LARGE | ENSP00000357384 | ENSP00000347088 | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | like-glycosyltransferase | 0.464 |
DPM3 | MGAT4C | ENSP00000357384 | ENSP00000331664 | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative); Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity) | 0.561 |
DPM3 | POMGNT1 | ENSP00000357384 | ENSP00000361052 | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O- Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity | 0.652 |
DPM3 | POMT1 | ENSP00000357384 | ENSP00000361302 | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | protein-O-mannosyltransferase 1 | 0.507 |
DPM3 | POMT2 | ENSP00000357384 | ENSP00000261534 | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | protein-O-mannosyltransferase 2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient | 0.676 |
FKRP | DAG1 | ENSP00000326570 | ENSP00000312435 | fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.873 |
FKRP | DPM3 | ENSP00000326570 | ENSP00000357384 | fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) | dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex | 0.408 |
FKRP | FKTN | ENSP00000326570 | ENSP00000223528 | fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) | fukutin; May be a glycosyltransferase which participates in glycosylation of alpha-dystroglycan/DAG1. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development | 0.872 |
FKRP | ISPD | ENSP00000326570 | ENSP00000385478 | fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) | isoprenoid synthase domain containing; Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation | 0.605 |
FKRP | LARGE | ENSP00000326570 | ENSP00000347088 | fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) | like-glycosyltransferase | 0.611 |