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DPM3 DPM3 DAG1 DAG1 LARGE LARGE MGAT4C MGAT4C POMT2 POMT2 POMT1 POMT1 FKRP FKRP POMGNT1 POMGNT1 FKTN FKTN ISPD ISPD GTDC2 GTDC2
"POMGNT1" - protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase in Homo sapiens
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Predicted Interactions
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POMGNT1protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O- Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity (660 aa)    
Predicted Functional Partners:
FKTN
fukutin; May be a glycosyltransferase which participates in glycosylation of alpha-dystroglycan/DAG1. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (461 aa)
            score_image   0.973
POMT1
protein-O-mannosyltransferase 1 (747 aa)
            score_image   0.932
POMT2
protein-O-mannosyltransferase 2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (750 aa)
            score_image   0.891
FKRP
fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) (495 aa)
            score_image   0.870
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization (895 aa)
            score_image   0.810
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative); Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity) (478 aa)
            score_image   0.745
ISPD
isoprenoid synthase domain containing; Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation (451 aa)
            score_image   0.723
DPM3
dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex (122 aa)
            score_image   0.652
GTDC2
glycosyltransferase-like domain containing 2 (580 aa)
            score_image   0.647
LARGE
like-glycosyltransferase (756 aa)
            score_image   0.634
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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