node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPA | ERGIC1 | ENSP00000357048 | ENSP00000377374 | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | 0.862 |
COPA | ERGIC2 | ENSP00000357048 | ENSP00000353270 | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | 0.430 |
COPA | LMAN1 | ENSP00000357048 | ENSP00000251047 | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | lectin, mannose-binding, 1 | 0.756 |
COPA | SURF2 | ENSP00000357048 | ENSP00000361032 | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | surfeit 2 | 0.489 |
COPA | SURF4 | ENSP00000357048 | ENSP00000361057 | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.757 |
COPA | TMED10 | ENSP00000357048 | ENSP00000303145 | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.785 |
COPA | TMED7 | ENSP00000357048 | ENSP00000405926 | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | transmembrane emp24 protein transport domain containing 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications | 0.720 |
ERGIC1 | COPA | ENSP00000377374 | ENSP00000357048 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | 0.862 |
ERGIC1 | LMAN1 | ENSP00000377374 | ENSP00000251047 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | lectin, mannose-binding, 1 | 0.755 |
ERGIC1 | SURF1 | ENSP00000377374 | ENSP00000361042 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | surfeit 1; Probably involved in the biogenesis of the COX complex | 0.414 |
ERGIC1 | SURF2 | ENSP00000377374 | ENSP00000361032 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | surfeit 2 | 0.657 |
ERGIC1 | SURF4 | ENSP00000377374 | ENSP00000361057 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.891 |
ERGIC1 | TMED10 | ENSP00000377374 | ENSP00000303145 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.475 |
ERGIC1 | TMED7 | ENSP00000377374 | ENSP00000405926 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | transmembrane emp24 protein transport domain containing 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications | 0.607 |
ERGIC2 | COPA | ENSP00000353270 | ENSP00000357048 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | 0.430 |
ERGIC2 | LMAN1 | ENSP00000353270 | ENSP00000251047 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | lectin, mannose-binding, 1 | 0.418 |
ERGIC2 | SEC61A1 | ENSP00000353270 | ENSP00000243253 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | Sec61 alpha 1 subunit (S. cerevisiae) | 0.451 |
ERGIC2 | SURF4 | ENSP00000353270 | ENSP00000361057 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | surfeit 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi | 0.764 |
ERGIC2 | TMED10 | ENSP00000353270 | ENSP00000303145 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.474 |
ERGIC2 | TMED7 | ENSP00000353270 | ENSP00000405926 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) | transmembrane emp24 protein transport domain containing 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications | 0.482 |