TSPAN14 protein (Homo sapiens) - STRING network view

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TSPAN14

tetraspanin 14 (270 aa)

Predicted Functional Partners:

DYDC2

0.651

UBC

0.620

ZDHHC7

0.531

HNRNPUL1

0.503

TMEM254

0.498

CD9

0.495

TSPAN31

0.489

HSPB9

0.471

TSPAN12

0.470

ZNF662

0.470

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD9	TSPAN14	ENSP00000009180	ENSP00000361229	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	tetraspanin 14	0.495
CD9	TSPAN31	ENSP00000009180	ENSP00000257910	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	tetraspanin 31	0.481
DYDC2	TMEM254	ENSP00000256039	ENSP00000361355	DPY30 domain containing 2	transmembrane protein 254	0.720
DYDC2	TSPAN14	ENSP00000256039	ENSP00000361229	DPY30 domain containing 2	tetraspanin 14	0.651
HNRNPUL1	TSPAN14	ENSP00000375863	ENSP00000361229	heterogeneous nuclear ribonucleoprotein U-like 1	tetraspanin 14	0.503
HNRNPUL1	UBC	ENSP00000375863	ENSP00000344818	heterogeneous nuclear ribonucleoprotein U-like 1	ubiquitin C	0.893
HSPB9	TSPAN14	ENSP00000347178	ENSP00000361229	heat shock protein, alpha-crystallin-related, B9	tetraspanin 14	0.471
HSPB9	ZDHHC7	ENSP00000347178	ENSP00000341681	heat shock protein, alpha-crystallin-related, B9	zinc finger, DHHC-type containing 7; Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear re [...]	0.498
TMEM254	DYDC2	ENSP00000361355	ENSP00000256039	transmembrane protein 254	DPY30 domain containing 2	0.720
TMEM254	TSPAN14	ENSP00000361355	ENSP00000361229	transmembrane protein 254	tetraspanin 14	0.498
TSPAN12	TSPAN14	ENSP00000222747	ENSP00000361229	tetraspanin 12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also p [...]	tetraspanin 14	0.470
TSPAN14	CD9	ENSP00000361229	ENSP00000009180	tetraspanin 14	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	0.495
TSPAN14	DYDC2	ENSP00000361229	ENSP00000256039	tetraspanin 14	DPY30 domain containing 2	0.651
TSPAN14	HNRNPUL1	ENSP00000361229	ENSP00000375863	tetraspanin 14	heterogeneous nuclear ribonucleoprotein U-like 1	0.503
TSPAN14	HSPB9	ENSP00000361229	ENSP00000347178	tetraspanin 14	heat shock protein, alpha-crystallin-related, B9	0.471
TSPAN14	TMEM254	ENSP00000361229	ENSP00000361355	tetraspanin 14	transmembrane protein 254	0.498
TSPAN14	TSPAN12	ENSP00000361229	ENSP00000222747	tetraspanin 14	tetraspanin 12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also p [...]	0.470
TSPAN14	TSPAN31	ENSP00000361229	ENSP00000257910	tetraspanin 14	tetraspanin 31	0.489
TSPAN14	UBC	ENSP00000361229	ENSP00000344818	tetraspanin 14	ubiquitin C	0.620
TSPAN14	ZDHHC7	ENSP00000361229	ENSP00000341681	tetraspanin 14	zinc finger, DHHC-type containing 7; Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear re [...]	0.531

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