Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ERI3 | ERI1 exoribonuclease family member 3 (337 aa) | ||||||||||||
Predicted Functional Partners:
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 | PRNP | prion protein (253 aa) |
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0.854 | |||||||||
 | UBC | ubiquitin C (685 aa) |
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0.721 | ||||||||||
 | TTK | TTK protein kinase; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (857 aa) |
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0.644 | ||||||||||
 | YTHDC2 | YTH domain containing 2 (1430 aa) |
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0.642 | ||||||||||
 | TOX2 | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system (506 aa) |
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0.634 | ||||||||||
 | G3BP2 | GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential) (482 aa) |
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0.576 | ||||||||||
 | SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission (706 aa) |
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0.565 | ||||||||||
 | GRB2 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (217 aa) |
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0.561 | ||||||||||
 | B4GALT2 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (401 aa) |
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0.560 | ||||||||||
 | NIPSNAP3A | nipsnap homolog 3A (C. elegans) (247 aa) |
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0.540 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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