node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
ACACA | CERS1 | ENSP00000344789 | ENSP00000402697 | acetyl-CoA carboxylase alpha | ceramide synthase 1; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity) | 0.467 |
ACACA | CERS2 | ENSP00000344789 | ENSP00000271688 | acetyl-CoA carboxylase alpha | ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis | 0.475 |
ACACA | CERS3 | ENSP00000344789 | ENSP00000284382 | acetyl-CoA carboxylase alpha | ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity) | 0.489 |
ACACA | CERS6 | ENSP00000344789 | ENSP00000306579 | acetyl-CoA carboxylase alpha | ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation (By similarity) | 0.483 |
ACACA | ELOVL1 | ENSP00000344789 | ENSP00000361536 | acetyl-CoA carboxylase alpha | ELOVL fatty acid elongase 1; Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22-0 acyl-CoA. Important for saturated C24-0 and monounsaturated C24-1 sphingolipid synthesis | 0.637 |
ACACA | HSD17B12 | ENSP00000344789 | ENSP00000278353 | acetyl-CoA carboxylase alpha | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | 0.481 |
ACACA | TECR | ENSP00000344789 | ENSP00000215567 | acetyl-CoA carboxylase alpha | trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids | 0.520 |
ACACA | TECRL | ENSP00000344789 | ENSP00000370607 | acetyl-CoA carboxylase alpha | trans-2,3-enoyl-CoA reductase-like | 0.517 |
ACACA | UBC | ENSP00000344789 | ENSP00000344818 | acetyl-CoA carboxylase alpha | ubiquitin C | 0.922 |
ACACB | ACACA | ENSP00000341044 | ENSP00000344789 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acetyl-CoA carboxylase alpha | 0.999 |
ACACB | CERS1 | ENSP00000341044 | ENSP00000402697 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ceramide synthase 1; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity) | 0.467 |
ACACB | CERS2 | ENSP00000341044 | ENSP00000271688 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis | 0.500 |
ACACB | CERS3 | ENSP00000341044 | ENSP00000284382 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity) | 0.467 |
ACACB | CERS6 | ENSP00000341044 | ENSP00000306579 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation (By similarity) | 0.467 |
ACACB | ELOVL1 | ENSP00000341044 | ENSP00000361536 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ELOVL fatty acid elongase 1; Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22-0 acyl-CoA. Important for saturated C24-0 and monounsaturated C24-1 sphingolipid synthesis | 0.657 |
ACACB | HSD17B12 | ENSP00000341044 | ENSP00000278353 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | 0.404 |
ACACB | TECR | ENSP00000341044 | ENSP00000215567 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids | 0.517 |
ACACB | TECRL | ENSP00000341044 | ENSP00000370607 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | trans-2,3-enoyl-CoA reductase-like | 0.517 |
ACACB | UBC | ENSP00000341044 | ENSP00000344818 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ubiquitin C | 0.851 |