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STRINGSTRING
CERS1 CERS1 HSD17B12 HSD17B12 TECR TECR CERS2 CERS2 TECRL TECRL UBC UBC ELOVL1 ELOVL1 ACACB ACACB ACACA ACACA CERS6 CERS6 CERS3 CERS3
"ELOVL1" - ELOVL fatty acid elongase 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
ELOVL1ELOVL fatty acid elongase 1; Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22-0 acyl-CoA. Important for saturated C24-0 and monounsaturated C24-1 sphingolipid synthesis (279 aa)    
Predicted Functional Partners:
TECR
trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids (308 aa)
      score_image score_image   score_image   0.932
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation (312 aa)
      score_image score_image   score_image   0.881
CERS2
ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis (380 aa)
      score_image score_image   score_image   0.876
UBC
ubiquitin C (685 aa)
        score_image       0.836
TECRL
trans-2,3-enoyl-CoA reductase-like (363 aa)
      score_image score_image   score_image   0.776
CERS3
ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity) (383 aa)
      score_image score_image   score_image   0.727
ACACB
acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
        score_image   score_image   0.657
CERS1
ceramide synthase 1; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity) (350 aa)
        score_image   score_image   0.653
CERS6
ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation (By similarity) (384 aa)
        score_image   score_image   0.646
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
        score_image   score_image   0.637
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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