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STRINGSTRING
AGT AGT HOXB13 HOXB13 USP20 USP20 C9orf78 C9orf78 DHODH DHODH PRRX2 PRRX2 PAX9 PAX9 FGF8 FGF8 SRF SRF FOXF2 FOXF2 FOXL1 FOXL1
"PRRX2" - paired related homeobox 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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Score
PRRX2paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development (253 aa)    
Predicted Functional Partners:
HOXB13
homeobox B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (284 aa)
            score_image   0.811
DHODH
dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (395 aa)
            score_image   0.811
PAX9
paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) (341 aa)
            score_image   0.748
SRF
serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation (508 aa)
        score_image   score_image   0.696
C9orf78
chromosome 9 open reading frame 78 (289 aa)
            score_image   0.643
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis (485 aa)
            score_image   0.563
FOXF2
forkhead box F2; Probable transcription activator for a number of lung- specific genes (444 aa)
        score_image   score_image   0.497
USP20
ubiquitin specific peptidase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitin [...] (914 aa)
            score_image   0.494
FGF8
fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (244 aa)
            score_image   0.474
FOXL1
forkhead box L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity) (345 aa)
        score_image   score_image   0.462
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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