node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | PRRX2 | ENSP00000355627 | ENSP00000361547 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | 0.563 |
C9orf78 | PRRX2 | ENSP00000361524 | ENSP00000361547 | chromosome 9 open reading frame 78 | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | 0.643 |
C9orf78 | USP20 | ENSP00000361524 | ENSP00000313811 | chromosome 9 open reading frame 78 | ubiquitin specific peptidase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitin [...] | 0.764 |
DHODH | HOXB13 | ENSP00000219240 | ENSP00000290295 | dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor | homeobox B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis | 0.485 |
DHODH | PAX9 | ENSP00000219240 | ENSP00000355245 | dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor | paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) | 0.516 |
DHODH | PRRX2 | ENSP00000219240 | ENSP00000361547 | dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | 0.811 |
FGF8 | PAX9 | ENSP00000321797 | ENSP00000355245 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) | 0.923 |
FGF8 | PRRX2 | ENSP00000321797 | ENSP00000361547 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | 0.474 |
FGF8 | SRF | ENSP00000321797 | ENSP00000265354 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.735 |
FOXF2 | PRRX2 | ENSP00000259806 | ENSP00000361547 | forkhead box F2; Probable transcription activator for a number of lung- specific genes | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | 0.497 |
FOXF2 | SRF | ENSP00000259806 | ENSP00000265354 | forkhead box F2; Probable transcription activator for a number of lung- specific genes | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.484 |
FOXL1 | PRRX2 | ENSP00000326272 | ENSP00000361547 | forkhead box L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity) | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | 0.462 |
FOXL1 | SRF | ENSP00000326272 | ENSP00000265354 | forkhead box L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity) | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.483 |
HOXB13 | DHODH | ENSP00000290295 | ENSP00000219240 | homeobox B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis | dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor | 0.485 |
HOXB13 | PRRX2 | ENSP00000290295 | ENSP00000361547 | homeobox B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | 0.811 |
PAX9 | DHODH | ENSP00000355245 | ENSP00000219240 | paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) | dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor | 0.516 |
PAX9 | FGF8 | ENSP00000355245 | ENSP00000321797 | paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.923 |
PAX9 | PRRX2 | ENSP00000355245 | ENSP00000361547 | paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | 0.748 |
PRRX2 | AGT | ENSP00000361547 | ENSP00000355627 | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.563 |
PRRX2 | C9orf78 | ENSP00000361547 | ENSP00000361524 | paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development | chromosome 9 open reading frame 78 | 0.643 |