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MBLAC1 MBLAC1 MIB2 MIB2 UBE2H UBE2H CISH CISH NEURL2 NEURL2 QPCT QPCT RBX1 RBX1 CTNNB1 CTNNB1 MYH3 MYH3 CYHR1 CYHR1 QPCTL QPCTL
"NEURL2" - neuralized homolog 2 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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[Homology]
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NEURL2neuralized homolog 2 (Drosophila); Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity) (285 aa)    
Predicted Functional Partners:
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction (1940 aa)
        score_image   score_image   0.843
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] (781 aa)
        score_image   score_image   0.749
MIB2
mindbomb E3 ubiquitin protein ligase 2 (1070 aa)
            score_image   0.611
CISH
cytokine inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteas [...] (275 aa)
            score_image   0.606
UBE2H
ubiquitin-conjugating enzyme E2H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’- and ’Lys-48’-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A (183 aa)
            score_image   0.587
RBX1
ring-box 1, E3 ubiquitin protein ligase; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in pr [...] (108 aa)
          score_image score_image   0.494
CYHR1
cysteine/histidine-rich 1 (362 aa)
            score_image   0.485
QPCT
glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides (361 aa)
            score_image   0.485
QPCTL
glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides (382 aa)
            score_image   0.485
MBLAC1
metallo-beta-lactamase domain containing 1 (266 aa)
            score_image   0.455
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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