CCDC23 protein (Homo sapiens) - STRING network view

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Score

CCDC23

coiled-coil domain containing 23 (66 aa)

Predicted Functional Partners:

VASH1

0.576

NUDCD2

0.501

CTTNBP2NL

0.472

TTI1

0.450

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC23	CTTNBP2NL	ENSP00000361599	ENSP00000271277	coiled-coil domain containing 23	CTTNBP2 N-terminal like	0.472
CCDC23	NUDCD2	ENSP00000361599	ENSP00000304854	coiled-coil domain containing 23	NudC domain containing 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone	0.501
CCDC23	TTI1	ENSP00000361599	ENSP00000362546	coiled-coil domain containing 23	TELO2 interacting protein 1; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell gr [...]	0.450
CCDC23	VASH1	ENSP00000361599	ENSP00000167106	coiled-coil domain containing 23	vasohibin 1; Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity	0.576
CTTNBP2NL	CCDC23	ENSP00000271277	ENSP00000361599	CTTNBP2 N-terminal like	coiled-coil domain containing 23	0.472
NUDCD2	CCDC23	ENSP00000304854	ENSP00000361599	NudC domain containing 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone	coiled-coil domain containing 23	0.501
TTI1	CCDC23	ENSP00000362546	ENSP00000361599	TELO2 interacting protein 1; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell gr [...]	coiled-coil domain containing 23	0.450
VASH1	CCDC23	ENSP00000167106	ENSP00000361599	vasohibin 1; Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity	coiled-coil domain containing 23	0.576

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