ZNF503 protein (Homo sapiens) - STRING network view

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Score

ZNF503

zinc finger protein 503; May function as a transcriptional repressor (By similarity) (646 aa)

Predicted Functional Partners:

AES

0.785

HOXC6

0.784

LHX3

0.781

EGR2

0.690

LHX4

0.606

KCNIP2

0.525

NGEF

0.510

KCNIP4

0.505

ANKRD49

0.446

CNTN4

0.422

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AES	HOXC6	ENSP00000221561	ENSP00000243108	amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state	homeobox C6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis	0.814
AES	ZNF503	ENSP00000221561	ENSP00000361602	amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.785
ANKRD49	ZNF503	ENSP00000303518	ENSP00000361602	ankyrin repeat domain 49	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.446
CNTN4	ZNF503	ENSP00000380602	ENSP00000361602	contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.422
EGR2	ZNF503	ENSP00000242480	ENSP00000361602	early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.690
HOXC6	AES	ENSP00000243108	ENSP00000221561	homeobox C6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis	amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state	0.814
HOXC6	ZNF503	ENSP00000243108	ENSP00000361602	homeobox C6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.784
KCNIP2	KCNIP4	ENSP00000420040	ENSP00000371587	Kv channel interacting protein 2	Kv channel interacting protein 4	0.525
KCNIP2	NGEF	ENSP00000420040	ENSP00000264051	Kv channel interacting protein 2	neuronal guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity)	0.544
KCNIP2	ZNF503	ENSP00000420040	ENSP00000361602	Kv channel interacting protein 2	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.525
KCNIP4	KCNIP2	ENSP00000371587	ENSP00000420040	Kv channel interacting protein 4	Kv channel interacting protein 2	0.525
KCNIP4	NGEF	ENSP00000371587	ENSP00000264051	Kv channel interacting protein 4	neuronal guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity)	0.505
KCNIP4	ZNF503	ENSP00000371587	ENSP00000361602	Kv channel interacting protein 4	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.505
LHX3	ZNF503	ENSP00000360811	ENSP00000361602	LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.781
LHX4	ZNF503	ENSP00000263726	ENSP00000361602	LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (By similarity)	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.606
NGEF	KCNIP2	ENSP00000264051	ENSP00000420040	neuronal guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity)	Kv channel interacting protein 2	0.544
NGEF	KCNIP4	ENSP00000264051	ENSP00000371587	neuronal guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity)	Kv channel interacting protein 4	0.505
NGEF	ZNF503	ENSP00000264051	ENSP00000361602	neuronal guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity)	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	0.510
ZNF503	AES	ENSP00000361602	ENSP00000221561	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state	0.785
ZNF503	ANKRD49	ENSP00000361602	ENSP00000303518	zinc finger protein 503; May function as a transcriptional repressor (By similarity)	ankyrin repeat domain 49	0.446

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