Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10; ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion (1492 aa) | ||||||||||||
Predicted Functional Partners:
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 | ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 (678 aa) |
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0.649 | |||||||||
 | ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 (845 aa) |
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0.625 | ||||||||||
 | ABCG4 | ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis (646 aa) |
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0.618 | |||||||||
 | ABCF2 | ATP-binding cassette, sub-family F (GCN20), member 2 (634 aa) |
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0.611 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.593 | |||||||||
 | TMEM104 | transmembrane protein 104 (496 aa) |
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0.593 | ||||||||||
 | ABCF3 | ATP-binding cassette, sub-family F (GCN20), member 3; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B (By similarity) (709 aa) |
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0.570 | ||||||||||
 | TOP2A | topoisomerase (DNA) II alpha 170kDa (1531 aa) |
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0.544 | ||||||||||
 | TOP2B | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (1621 aa) |
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0.544 | ||||||||||
 | MRPS7 | mitochondrial ribosomal protein S7 (242 aa) |
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0.538 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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