SLC22A7 protein (Homo sapiens) - STRING network view

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SLC22A7

solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate (548 aa)

Predicted Functional Partners:

SLCO2B1

0.775

SLCO1B1

0.741

SLCO1A2

0.734

SLC26A6

0.715

SLC15A1

0.680

SLCO1C1

0.668

SLCO3A1

0.651

ENSG00000257046

0.636

ABCC4

0.634

SLCO1B3

0.633

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC4	ENSG00000257046	ENSP00000366084	ENSP00000441269	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein	0.716
ABCC4	SLC15A1	ENSP00000366084	ENSP00000365686	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products	0.497
ABCC4	SLC22A7	ENSP00000366084	ENSP00000361666	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate	0.634
ABCC4	SLC26A6	ENSP00000366084	ENSP00000378920	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier family 26, member 6; Does not seem to be involved in anion transport	0.691
ABCC4	SLCO1A2	ENSP00000366084	ENSP00000305974	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin	0.738
ABCC4	SLCO1B1	ENSP00000366084	ENSP00000256958	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver	0.739
ABCC4	SLCO1B3	ENSP00000366084	ENSP00000261196	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier organic anion transporter family, member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver	0.716
ABCC4	SLCO1C1	ENSP00000366084	ENSP00000370964	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity)	0.588
ABCC4	SLCO2B1	ENSP00000366084	ENSP00000289575	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier organic anion transporter family, member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity)	0.608
ABCC4	SLCO3A1	ENSP00000366084	ENSP00000320634	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	solute carrier organic anion transporter family, member 3A1; Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed-10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed-16971491)	0.429
ENSG00000257046	ABCC4	ENSP00000441269	ENSP00000366084	Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	0.716
ENSG00000257046	SLC15A1	ENSP00000441269	ENSP00000365686	Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein	solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products	0.552
ENSG00000257046	SLC22A7	ENSP00000441269	ENSP00000361666	Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein	solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate	0.636
ENSG00000257046	SLC26A6	ENSP00000441269	ENSP00000378920	Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein	solute carrier family 26, member 6; Does not seem to be involved in anion transport	0.416
SLC15A1	ABCC4	ENSP00000365686	ENSP00000366084	solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products	ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification	0.497
SLC15A1	ENSG00000257046	ENSP00000365686	ENSP00000441269	solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products	Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein	0.552
SLC15A1	SLC22A7	ENSP00000365686	ENSP00000361666	solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products	solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate	0.680
SLC15A1	SLC26A6	ENSP00000365686	ENSP00000378920	solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products	solute carrier family 26, member 6; Does not seem to be involved in anion transport	0.510
SLC15A1	SLCO1A2	ENSP00000365686	ENSP00000305974	solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products	solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin	0.658
SLC15A1	SLCO1B1	ENSP00000365686	ENSP00000256958	solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products	solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver	0.601

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