| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABTB1 | DNTTIP1 | ENSP00000232744 | ENSP00000361705 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | 0.651 |
| COQ10A | DNTTIP1 | ENSP00000312587 | ENSP00000361705 | coenzyme Q10 homolog A (S. cerevisiae); Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable) | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | 0.674 |
| DNTT | DNTTIP1 | ENSP00000360216 | ENSP00000361705 | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | 0.889 |
| DNTT | TRERF1 | ENSP00000360216 | ENSP00000362013 | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells | transcriptional regulating factor 1; Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1 | 0.800 |
| DNTTIP1 | ABTB1 | ENSP00000361705 | ENSP00000232744 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | 0.651 |
| DNTTIP1 | COQ10A | ENSP00000361705 | ENSP00000312587 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | coenzyme Q10 homolog A (S. cerevisiae); Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable) | 0.674 |
| DNTTIP1 | DNTT | ENSP00000361705 | ENSP00000360216 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells | 0.889 |
| DNTTIP1 | ELMSAN1 | ENSP00000361705 | ENSP00000286523 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | ELM2 and Myb/SANT-like domain containing 1 | 0.779 |
| DNTTIP1 | HDAC1 | ENSP00000361705 | ENSP00000362649 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.746 |
| DNTTIP1 | HDAC2 | ENSP00000361705 | ENSP00000430432 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.763 |
| DNTTIP1 | HMGA2 | ENSP00000361705 | ENSP00000384026 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | high mobility group AT-hook 2; Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes (By similarity) | 0.683 |
| DNTTIP1 | RAB20 | ENSP00000361705 | ENSP00000267328 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | RAB20, member RAS oncogene family; Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes | 0.826 |
| DNTTIP1 | TRERF1 | ENSP00000361705 | ENSP00000362013 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | transcriptional regulating factor 1; Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1 | 0.791 |
| DNTTIP1 | ZNF541 | ENSP00000361705 | ENSP00000313258 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity) | 0.737 |
| ELMSAN1 | DNTTIP1 | ENSP00000286523 | ENSP00000361705 | ELM2 and Myb/SANT-like domain containing 1 | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | 0.779 |
| ELMSAN1 | HDAC1 | ENSP00000286523 | ENSP00000362649 | ELM2 and Myb/SANT-like domain containing 1 | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.756 |
| ELMSAN1 | HDAC2 | ENSP00000286523 | ENSP00000430432 | ELM2 and Myb/SANT-like domain containing 1 | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.759 |
| HDAC1 | DNTTIP1 | ENSP00000362649 | ENSP00000361705 | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | 0.746 |
| HDAC1 | ELMSAN1 | ENSP00000362649 | ENSP00000286523 | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | ELM2 and Myb/SANT-like domain containing 1 | 0.756 |
| HDAC1 | HDAC2 | ENSP00000362649 | ENSP00000430432 | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.999 |
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