| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAP2 | ARF1 | ENSP00000324287 | ENSP00000272102 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | 0.772 |
| ACAP2 | ARF3 | ENSP00000324287 | ENSP00000256682 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus | 0.443 |
| ACAP2 | ARF4 | ENSP00000324287 | ENSP00000306010 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) | ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus | 0.539 |
| ACAP2 | ARF5 | ENSP00000324287 | ENSP00000000233 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) | ADP-ribosylation factor 5; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus | 0.849 |
| ACAP2 | ARFGAP1 | ENSP00000324287 | ENSP00000314615 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) | ADP-ribosylation factor GTPase activating protein 1 | 0.744 |
| ACAP2 | SMAP2 | ENSP00000324287 | ENSP00000361803 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) | small ArfGAP2 | 0.585 |
| APPL1 | APPL2 | ENSP00000288266 | ENSP00000258530 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction | 0.960 |
| APPL1 | ARF1 | ENSP00000288266 | ENSP00000272102 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | 0.404 |
| APPL1 | ARFGAP1 | ENSP00000288266 | ENSP00000314615 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | ADP-ribosylation factor GTPase activating protein 1 | 0.684 |
| APPL1 | SMAP2 | ENSP00000288266 | ENSP00000361803 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | small ArfGAP2 | 0.664 |
| APPL2 | APPL1 | ENSP00000258530 | ENSP00000288266 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | 0.960 |
| APPL2 | ARFGAP1 | ENSP00000258530 | ENSP00000314615 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction | ADP-ribosylation factor GTPase activating protein 1 | 0.654 |
| APPL2 | SMAP2 | ENSP00000258530 | ENSP00000361803 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction | small ArfGAP2 | 0.664 |
| ARF1 | ACAP2 | ENSP00000272102 | ENSP00000324287 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) | 0.772 |
| ARF1 | APPL1 | ENSP00000272102 | ENSP00000288266 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | 0.404 |
| ARF1 | ARF3 | ENSP00000272102 | ENSP00000256682 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus | 0.646 |
| ARF1 | ARFGAP1 | ENSP00000272102 | ENSP00000314615 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | ADP-ribosylation factor GTPase activating protein 1 | 0.999 |
| ARF1 | SMAP2 | ENSP00000272102 | ENSP00000361803 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | small ArfGAP2 | 0.692 |
| ARF3 | ACAP2 | ENSP00000256682 | ENSP00000324287 | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) | 0.443 |
| ARF3 | ARF1 | ENSP00000256682 | ENSP00000272102 | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | 0.646 |
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