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STRINGSTRING
MAGOH MAGOH SPTB SPTB SPTBN1 SPTBN1 KCNQ2 KCNQ2 ANK1 ANK1 SPTAN1 SPTAN1 SPTBN2 SPTBN2 ACTA1 ACTA1 SRC SRC CAPN1 CAPN1 CASP3 CASP3
"SPTAN1" - spectrin, alpha, non-erythrocytic 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
SPTAN1spectrin, alpha, non-erythrocytic 1 (2477 aa)    
Predicted Functional Partners:
SPTBN1
spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa)
        score_image score_image score_image score_image 0.999
MAGOH
mago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] (146 aa)
        score_image       0.996
ACTA1
actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
        score_image score_image score_image   0.993
SPTB
spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2328 aa)
        score_image score_image score_image score_image 0.984
CASP3
caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (277 aa)
        score_image score_image score_image   0.975
KCNQ2
potassium voltage-gated channel, KQT-like subfamily, member 2 (872 aa)
          score_image score_image   0.974
SPTBN2
spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton (2390 aa)
        score_image score_image score_image score_image 0.968
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] (536 aa)
        score_image score_image score_image   0.966
ANK1
ankyrin 1, erythrocytic (1897 aa)
      score_image score_image score_image score_image   0.961
CAPN1
calpain 1, (mu/I) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (714 aa)
        score_image score_image score_image   0.956
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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