node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL11A1 | COL12A1 | ENSP00000359114 | ENSP00000325146 | collagen, type XI, alpha 1 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | 0.918 |
COL11A1 | COL23A1 | ENSP00000359114 | ENSP00000375069 | collagen, type XI, alpha 1 | collagen, type XXIII, alpha 1 | 0.902 |
COL11A1 | COL25A1 | ENSP00000359114 | ENSP00000382083 | collagen, type XI, alpha 1 | collagen, type XXV, alpha 1; Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin | 0.901 |
COL11A1 | COL2A1 | ENSP00000359114 | ENSP00000369889 | collagen, type XI, alpha 1 | collagen, type II, alpha 1 | 0.928 |
COL11A1 | COL3A1 | ENSP00000359114 | ENSP00000304408 | collagen, type XI, alpha 1 | collagen, type III, alpha 1 | 0.920 |
COL11A1 | COL5A1 | ENSP00000359114 | ENSP00000360882 | collagen, type XI, alpha 1 | collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin | 0.902 |
COL11A1 | COL9A2 | ENSP00000359114 | ENSP00000361834 | collagen, type XI, alpha 1 | collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye | 0.921 |
COL11A1 | COL9A3 | ENSP00000359114 | ENSP00000341640 | collagen, type XI, alpha 1 | collagen, type IX, alpha 3; Structural component of hyaline cartilage and vitreous of the eye | 0.920 |
COL12A1 | COL11A1 | ENSP00000325146 | ENSP00000359114 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XI, alpha 1 | 0.918 |
COL12A1 | COL23A1 | ENSP00000325146 | ENSP00000375069 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XXIII, alpha 1 | 0.910 |
COL12A1 | COL25A1 | ENSP00000325146 | ENSP00000382083 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XXV, alpha 1; Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin | 0.917 |
COL12A1 | COL2A1 | ENSP00000325146 | ENSP00000369889 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type II, alpha 1 | 0.918 |
COL12A1 | COL3A1 | ENSP00000325146 | ENSP00000304408 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type III, alpha 1 | 0.948 |
COL12A1 | COL5A1 | ENSP00000325146 | ENSP00000360882 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin | 0.952 |
COL12A1 | COL9A2 | ENSP00000325146 | ENSP00000361834 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye | 0.932 |
COL12A1 | COL9A3 | ENSP00000325146 | ENSP00000341640 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type IX, alpha 3; Structural component of hyaline cartilage and vitreous of the eye | 0.901 |
COL12A1 | MMP2 | ENSP00000325146 | ENSP00000219070 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] | 0.916 |
COL12A1 | MMP9 | ENSP00000325146 | ENSP00000361405 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide | 0.911 |
COL23A1 | COL11A1 | ENSP00000375069 | ENSP00000359114 | collagen, type XXIII, alpha 1 | collagen, type XI, alpha 1 | 0.902 |
COL23A1 | COL12A1 | ENSP00000375069 | ENSP00000325146 | collagen, type XXIII, alpha 1 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | 0.910 |