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STRINGSTRING
MMP2 MMP2 MMP9 MMP9 COL12A1 COL12A1 COL3A1 COL3A1 COL9A2 COL9A2 COL9A3 COL9A3 COL2A1 COL2A1 COL23A1 COL23A1 COL5A1 COL5A1 COL11A1 COL11A1 COL25A1 COL25A1
"COL9A2" - collagen, type IX, alpha 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
COL9A2collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye (689 aa)    
Predicted Functional Partners:
COL2A1
collagen, type II, alpha 1 (1487 aa)
        score_image score_image score_image score_image 0.966
COL12A1
collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) (3063 aa)
          score_image score_image   0.932
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] (660 aa)
          score_image score_image   0.929
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (707 aa)
          score_image score_image   0.926
COL3A1
collagen, type III, alpha 1 (1466 aa)
          score_image score_image   0.926
COL11A1
collagen, type XI, alpha 1 (1806 aa)
          score_image score_image score_image 0.921
COL9A3
collagen, type IX, alpha 3; Structural component of hyaline cartilage and vitreous of the eye (684 aa)
          score_image score_image score_image 0.921
COL23A1
collagen, type XXIII, alpha 1 (540 aa)
    score_image     score_image score_image score_image 0.919
COL25A1
collagen, type XXV, alpha 1; Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (654 aa)
    score_image     score_image score_image score_image 0.918
COL5A1
collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1838 aa)
          score_image score_image score_image 0.916
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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