| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| B2M | CST3 | ENSP00000452780 | ENSP00000366124 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | 0.969 |
| B2M | GSN | ENSP00000452780 | ENSP00000362924 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis | 0.925 |
| B2M | HSPG2 | ENSP00000452780 | ENSP00000363827 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.918 |
| B2M | IAPP | ENSP00000452780 | ENSP00000240652 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism | 0.928 |
| B2M | LTF | ENSP00000452780 | ENSP00000231751 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | lactotransferrin | 0.910 |
| B2M | LYZ | ENSP00000452780 | ENSP00000261267 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents | 0.956 |
| B2M | SAA1 | ENSP00000452780 | ENSP00000348918 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | serum amyloid A1; Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity) | 0.921 |
| B2M | SEMG1 | ENSP00000452780 | ENSP00000361867 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | semenogelin I | 0.904 |
| B2M | TTR | ENSP00000452780 | ENSP00000237014 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain | 0.948 |
| CST3 | B2M | ENSP00000366124 | ENSP00000452780 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | 0.969 |
| CST3 | GSN | ENSP00000366124 | ENSP00000362924 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis | 0.947 |
| CST3 | HSPG2 | ENSP00000366124 | ENSP00000363827 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.915 |
| CST3 | IAPP | ENSP00000366124 | ENSP00000240652 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism | 0.923 |
| CST3 | LTF | ENSP00000366124 | ENSP00000231751 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | lactotransferrin | 0.913 |
| CST3 | LYZ | ENSP00000366124 | ENSP00000261267 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents | 0.944 |
| CST3 | SAA1 | ENSP00000366124 | ENSP00000348918 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | serum amyloid A1; Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity) | 0.923 |
| CST3 | SEMG1 | ENSP00000366124 | ENSP00000361867 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | semenogelin I | 0.906 |
| CST3 | TTR | ENSP00000366124 | ENSP00000237014 | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain | 0.961 |
| EPPIN | LTF | ENSP00000452085 | ENSP00000231751 | epididymal peptidase inhibitor; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility | lactotransferrin | 0.414 |
| EPPIN | SEMG1 | ENSP00000452085 | ENSP00000361867 | epididymal peptidase inhibitor; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility | semenogelin I | 0.909 |
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