OXCT2 protein (Homo sapiens) - STRING network view

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OXCT2

3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) (517 aa)

Predicted Functional Partners:

OXCT1

0.996

ACAT2

0.982

ACAT1

0.982

EHHADH

0.970

HADH

0.959

HMGCL

0.947

HMGCS1

0.919

HMGCS2

0.918

BDH2

0.909

BDH1

0.906

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	ACAT2	ENSP00000265838	ENSP00000356015	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	acetyl-CoA acetyltransferase 2	0.841
ACAT1	BDH1	ENSP00000265838	ENSP00000350914	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-hydroxybutyrate dehydrogenase, type 1	0.497
ACAT1	EHHADH	ENSP00000265838	ENSP00000231887	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.998
ACAT1	HADH	ENSP00000265838	ENSP00000385638	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA	0.984
ACAT1	HMGCL	ENSP00000265838	ENSP00000363614	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism	0.936
ACAT1	HMGCS1	ENSP00000265838	ENSP00000322706	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.992
ACAT1	HMGCS2	ENSP00000265838	ENSP00000358414	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.986
ACAT1	OXCT1	ENSP00000265838	ENSP00000196371	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)	0.989
ACAT1	OXCT2	ENSP00000265838	ENSP00000361914	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)	0.982
ACAT2	ACAT1	ENSP00000356015	ENSP00000265838	acetyl-CoA acetyltransferase 2	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.841
ACAT2	EHHADH	ENSP00000356015	ENSP00000231887	acetyl-CoA acetyltransferase 2	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.998
ACAT2	HADH	ENSP00000356015	ENSP00000385638	acetyl-CoA acetyltransferase 2	hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA	0.981
ACAT2	HMGCL	ENSP00000356015	ENSP00000363614	acetyl-CoA acetyltransferase 2	3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism	0.938
ACAT2	HMGCS1	ENSP00000356015	ENSP00000322706	acetyl-CoA acetyltransferase 2	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.990
ACAT2	HMGCS2	ENSP00000356015	ENSP00000358414	acetyl-CoA acetyltransferase 2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.980
ACAT2	OXCT1	ENSP00000356015	ENSP00000196371	acetyl-CoA acetyltransferase 2	3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)	0.985
ACAT2	OXCT2	ENSP00000356015	ENSP00000361914	acetyl-CoA acetyltransferase 2	3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)	0.982
BDH1	ACAT1	ENSP00000350914	ENSP00000265838	3-hydroxybutyrate dehydrogenase, type 1	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.497
BDH1	BDH2	ENSP00000350914	ENSP00000296424	3-hydroxybutyrate dehydrogenase, type 1	3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)	0.952
BDH1	HMGCL	ENSP00000350914	ENSP00000363614	3-hydroxybutyrate dehydrogenase, type 1	3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism	0.943

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