node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | POU3F1 | ENSP00000368104 | ENSP00000362103 | bone morphogenetic protein 2; Induces cartilage and bone formation | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.739 |
BMP2 | POU3F3 | ENSP00000368104 | ENSP00000355001 | bone morphogenetic protein 2; Induces cartilage and bone formation | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | 0.740 |
BMP4 | BMP2 | ENSP00000245451 | ENSP00000368104 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.903 |
BMP4 | EGR2 | ENSP00000245451 | ENSP00000242480 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | 0.532 |
BMP4 | HOXA5 | ENSP00000245451 | ENSP00000222726 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | homeobox A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5’-CYYNATTA[TG]Y-3’ | 0.400 |
BMP4 | POU3F1 | ENSP00000245451 | ENSP00000362103 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.762 |
BMP4 | POU3F3 | ENSP00000245451 | ENSP00000355001 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | 0.766 |
BMP4 | SLIT3 | ENSP00000245451 | ENSP00000430333 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | slit homolog 3 (Drosophila); May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors | 0.415 |
EGR2 | BMP4 | ENSP00000242480 | ENSP00000245451 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.532 |
EGR2 | PMP22 | ENSP00000242480 | ENSP00000308937 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system | 0.912 |
EGR2 | POU3F1 | ENSP00000242480 | ENSP00000362103 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.956 |
EGR2 | POU3F3 | ENSP00000242480 | ENSP00000355001 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | 0.491 |
HOXA5 | BMP4 | ENSP00000222726 | ENSP00000245451 | homeobox A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5’-CYYNATTA[TG]Y-3’ | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.400 |
HOXA5 | POU3F1 | ENSP00000222726 | ENSP00000362103 | homeobox A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5’-CYYNATTA[TG]Y-3’ | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.796 |
HOXA5 | POU3F3 | ENSP00000222726 | ENSP00000355001 | homeobox A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5’-CYYNATTA[TG]Y-3’ | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | 0.405 |
HOXB5 | POU3F1 | ENSP00000239151 | ENSP00000362103 | homeobox B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.697 |
HOXB5 | POU3F3 | ENSP00000239151 | ENSP00000355001 | homeobox B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | 0.405 |
PMP22 | EGR2 | ENSP00000308937 | ENSP00000242480 | peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | 0.912 |
PMP22 | POU3F1 | ENSP00000308937 | ENSP00000362103 | peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.878 |