node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000248710 | IFT122 | ENSP00000456272 | ENSP00000296266 | Uncharacterized protein | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | 0.718 |
ENSG00000248710 | IFT140 | ENSP00000456272 | ENSP00000406012 | Uncharacterized protein | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | 0.841 |
ENSG00000248710 | IFT27 | ENSP00000456272 | ENSP00000393541 | Uncharacterized protein | intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) | 0.730 |
ENSG00000248710 | IFT46 | ENSP00000456272 | ENSP00000264020 | Uncharacterized protein | intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity) | 0.842 |
ENSG00000248710 | IFT52 | ENSP00000456272 | ENSP00000362121 | Uncharacterized protein | intraflagellar transport 52 homolog (Chlamydomonas) | 0.848 |
ENSG00000248710 | IFT57 | ENSP00000456272 | ENSP00000264538 | Uncharacterized protein | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | 0.841 |
ENSG00000248710 | IFT88 | ENSP00000456272 | ENSP00000323580 | Uncharacterized protein | intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity) | 0.823 |
ENSG00000248710 | TTC21B | ENSP00000456272 | ENSP00000243344 | Uncharacterized protein | tetratricopeptide repeat domain 21B | 0.647 |
IFT122 | ENSG00000248710 | ENSP00000296266 | ENSP00000456272 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | Uncharacterized protein | 0.718 |
IFT122 | IFT140 | ENSP00000296266 | ENSP00000406012 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | 0.975 |
IFT122 | IFT172 | ENSP00000296266 | ENSP00000260570 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity) | 0.714 |
IFT122 | IFT27 | ENSP00000296266 | ENSP00000393541 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) | 0.812 |
IFT122 | IFT46 | ENSP00000296266 | ENSP00000264020 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity) | 0.625 |
IFT122 | IFT52 | ENSP00000296266 | ENSP00000362121 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 52 homolog (Chlamydomonas) | 0.850 |
IFT122 | IFT57 | ENSP00000296266 | ENSP00000264538 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | 0.580 |
IFT122 | IFT80 | ENSP00000296266 | ENSP00000312778 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia | 0.719 |
IFT122 | IFT88 | ENSP00000296266 | ENSP00000323580 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity) | 0.854 |
IFT122 | TTC21B | ENSP00000296266 | ENSP00000243344 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | tetratricopeptide repeat domain 21B | 0.954 |
IFT140 | ENSG00000248710 | ENSP00000406012 | ENSP00000456272 | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | Uncharacterized protein | 0.841 |
IFT140 | IFT122 | ENSP00000406012 | ENSP00000296266 | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | 0.975 |