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STRINGSTRING
NCKAP1 NCKAP1 NCKAP1L NCKAP1L SCN1A SCN1A PCDH19 PCDH19 ARX ARX KCNQ2 KCNQ2 SPTAN1 SPTAN1 SCN2A SCN2A PLCB1 PLCB1 PNKP PNKP SLC25A22 SLC25A22
"PCDH19" - protocadherin 19 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCDH19protocadherin 19; Potential calcium-dependent cell-adhesion protein (1148 aa)    
Predicted Functional Partners:
KCNQ2
potassium voltage-gated channel, KQT-like subfamily, member 2 (872 aa)
            score_image   0.748
ARX
aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (562 aa)
            score_image   0.680
SCN1A
sodium channel, voltage-gated, type I, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (2009 aa)
            score_image   0.661
NCKAP1
NCK-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (1134 aa)
            score_image   0.651
SLC25A22
solute carrier family 25 (mitochondrial carrier- glutamate), member 22 (323 aa)
            score_image   0.610
PNKP
polynucleotide kinase 3’-phosphatase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3’-phosphates from, or by phosphorylating 5’-hydroxyl groups on, the ribose sugar of the DNA backbone (521 aa)
            score_image   0.608
SPTAN1
spectrin, alpha, non-erythrocytic 1 (2477 aa)
            score_image   0.607
NCKAP1L
NCK-associated protein 1-like (1127 aa)
            score_image   0.576
SCN2A
sodium channel, voltage-gated, type II, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (2005 aa)
            score_image   0.562
PLCB1
phospholipase C, beta 1 (phosphoinositide-specific) (1216 aa)
            score_image   0.560
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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