node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARX | KCNQ2 | ENSP00000368332 | ENSP00000352035 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | potassium voltage-gated channel, KQT-like subfamily, member 2 | 0.861 |
ARX | PCDH19 | ENSP00000368332 | ENSP00000362125 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | protocadherin 19; Potential calcium-dependent cell-adhesion protein | 0.680 |
ARX | PLCB1 | ENSP00000368332 | ENSP00000338185 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | phospholipase C, beta 1 (phosphoinositide-specific) | 0.610 |
ARX | PNKP | ENSP00000368332 | ENSP00000323511 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | polynucleotide kinase 3’-phosphatase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3’-phosphates from, or by phosphorylating 5’-hydroxyl groups on, the ribose sugar of the DNA backbone | 0.682 |
ARX | SCN1A | ENSP00000368332 | ENSP00000303540 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | sodium channel, voltage-gated, type I, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient | 0.606 |
ARX | SLC25A22 | ENSP00000368332 | ENSP00000322020 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | solute carrier family 25 (mitochondrial carrier- glutamate), member 22 | 0.608 |
ARX | SPTAN1 | ENSP00000368332 | ENSP00000361824 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | spectrin, alpha, non-erythrocytic 1 | 0.742 |
KCNQ2 | ARX | ENSP00000352035 | ENSP00000368332 | potassium voltage-gated channel, KQT-like subfamily, member 2 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | 0.861 |
KCNQ2 | PCDH19 | ENSP00000352035 | ENSP00000362125 | potassium voltage-gated channel, KQT-like subfamily, member 2 | protocadherin 19; Potential calcium-dependent cell-adhesion protein | 0.748 |
KCNQ2 | PLCB1 | ENSP00000352035 | ENSP00000338185 | potassium voltage-gated channel, KQT-like subfamily, member 2 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.700 |
KCNQ2 | PNKP | ENSP00000352035 | ENSP00000323511 | potassium voltage-gated channel, KQT-like subfamily, member 2 | polynucleotide kinase 3’-phosphatase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3’-phosphates from, or by phosphorylating 5’-hydroxyl groups on, the ribose sugar of the DNA backbone | 0.749 |
KCNQ2 | SCN1A | ENSP00000352035 | ENSP00000303540 | potassium voltage-gated channel, KQT-like subfamily, member 2 | sodium channel, voltage-gated, type I, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient | 0.586 |
KCNQ2 | SCN2A | ENSP00000352035 | ENSP00000283256 | potassium voltage-gated channel, KQT-like subfamily, member 2 | sodium channel, voltage-gated, type II, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient | 0.720 |
KCNQ2 | SLC25A22 | ENSP00000352035 | ENSP00000322020 | potassium voltage-gated channel, KQT-like subfamily, member 2 | solute carrier family 25 (mitochondrial carrier- glutamate), member 22 | 0.752 |
KCNQ2 | SPTAN1 | ENSP00000352035 | ENSP00000361824 | potassium voltage-gated channel, KQT-like subfamily, member 2 | spectrin, alpha, non-erythrocytic 1 | 0.974 |
NCKAP1 | NCKAP1L | ENSP00000354251 | ENSP00000293373 | NCK-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 | NCK-associated protein 1-like | 0.724 |
NCKAP1 | PCDH19 | ENSP00000354251 | ENSP00000362125 | NCK-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 | protocadherin 19; Potential calcium-dependent cell-adhesion protein | 0.651 |
NCKAP1L | NCKAP1 | ENSP00000293373 | ENSP00000354251 | NCK-associated protein 1-like | NCK-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 | 0.724 |
NCKAP1L | PCDH19 | ENSP00000293373 | ENSP00000362125 | NCK-associated protein 1-like | protocadherin 19; Potential calcium-dependent cell-adhesion protein | 0.576 |
PCDH19 | ARX | ENSP00000362125 | ENSP00000368332 | protocadherin 19; Potential calcium-dependent cell-adhesion protein | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | 0.680 |