MTF1 protein (Homo sapiens) - STRING network view

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MTF1

metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE) (753 aa)

Predicted Functional Partners:

SLC30A1

0.927

EP300

0.876

CREBBP

0.876

SLC39A10

0.858

HDAC9

0.844

MT2A

0.822

MT1E

0.806

MT1A

0.801

GCLM

0.753

MT1X

0.741

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	EP300	ENSP00000262367	ENSP00000263253	CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300	E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...]	0.992
CREBBP	HDAC9	ENSP00000262367	ENSP00000408617	CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300	histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription	0.983
CREBBP	MTF1	ENSP00000262367	ENSP00000362127	CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	0.876
EP300	CREBBP	ENSP00000263253	ENSP00000262367	E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...]	CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300	0.992
EP300	HDAC9	ENSP00000263253	ENSP00000408617	E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...]	histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription	0.989
EP300	MTF1	ENSP00000263253	ENSP00000362127	E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...]	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	0.876
GCLM	MTF1	ENSP00000359258	ENSP00000362127	glutamate-cysteine ligase, modifier subunit	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	0.753
HDAC9	CREBBP	ENSP00000408617	ENSP00000262367	histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription	CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300	0.983
HDAC9	EP300	ENSP00000408617	ENSP00000263253	histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription	E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...]	0.989
HDAC9	MTF1	ENSP00000408617	ENSP00000362127	histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	0.844
MT1A	MTF1	ENSP00000290705	ENSP00000362127	metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	0.801
MT1E	MTF1	ENSP00000307706	ENSP00000362127	metallothionein 1E; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity)	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	0.806
MT1X	MTF1	ENSP00000377995	ENSP00000362127	metallothionein 1X; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	0.741
MT1X	SLC30A1	ENSP00000377995	ENSP00000355968	metallothionein 1X; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids	solute carrier family 30 (zinc transporter), member 1; May be involved in zinc transport out of the cell	0.400
MT2A	MTF1	ENSP00000245185	ENSP00000362127	metallothionein 2A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	0.822
MT2A	SLC30A1	ENSP00000245185	ENSP00000355968	metallothionein 2A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids	solute carrier family 30 (zinc transporter), member 1; May be involved in zinc transport out of the cell	0.431
MTF1	CREBBP	ENSP00000362127	ENSP00000262367	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300	0.876
MTF1	EP300	ENSP00000362127	ENSP00000263253	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...]	0.876
MTF1	GCLM	ENSP00000362127	ENSP00000359258	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	glutamate-cysteine ligase, modifier subunit	0.753
MTF1	HDAC9	ENSP00000362127	ENSP00000408617	metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)	histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription	0.844

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