FAM102A protein (Homo sapiens) - STRING network view

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FAM102A

family with sequence similarity 102, member A; May play a role in estrogen action (384 aa)

Predicted Functional Partners:

SKAP1

0.590

ENKD1

0.520

ESR1

0.520

SH3GL1

0.512

SRP72

0.485

WDR44

0.483

ESRP2

0.461

ESRP1

0.461

MDGA1

0.403

MDGA2

0.403

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENKD1	FAM102A	ENSP00000243878	ENSP00000362187	enkurin domain containing 1	family with sequence similarity 102, member A; May play a role in estrogen action	0.520
ESR1	FAM102A	ENSP00000206249	ENSP00000362187	estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...]	family with sequence similarity 102, member A; May play a role in estrogen action	0.520
ESRP1	FAM102A	ENSP00000405738	ENSP00000362187	epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2	family with sequence similarity 102, member A; May play a role in estrogen action	0.461
ESRP1	WDR44	ENSP00000405738	ENSP00000254029	epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2	WD repeat domain 44	0.516
ESRP2	FAM102A	ENSP00000418748	ENSP00000362187	epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2	family with sequence similarity 102, member A; May play a role in estrogen action	0.461
ESRP2	WDR44	ENSP00000418748	ENSP00000254029	epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2	WD repeat domain 44	0.516
FAM102A	ENKD1	ENSP00000362187	ENSP00000243878	family with sequence similarity 102, member A; May play a role in estrogen action	enkurin domain containing 1	0.520
FAM102A	ESR1	ENSP00000362187	ENSP00000206249	family with sequence similarity 102, member A; May play a role in estrogen action	estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...]	0.520
FAM102A	ESRP1	ENSP00000362187	ENSP00000405738	family with sequence similarity 102, member A; May play a role in estrogen action	epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2	0.461
FAM102A	ESRP2	ENSP00000362187	ENSP00000418748	family with sequence similarity 102, member A; May play a role in estrogen action	epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2	0.461
FAM102A	MDGA1	ENSP00000362187	ENSP00000402584	family with sequence similarity 102, member A; May play a role in estrogen action	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	0.403
FAM102A	MDGA2	ENSP00000362187	ENSP00000382178	family with sequence similarity 102, member A; May play a role in estrogen action	MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity)	0.403
FAM102A	SH3GL1	ENSP00000362187	ENSP00000269886	family with sequence similarity 102, member A; May play a role in estrogen action	SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)	0.512
FAM102A	SKAP1	ENSP00000362187	ENSP00000338171	family with sequence similarity 102, member A; May play a role in estrogen action	src kinase associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells	0.590
FAM102A	SRP72	ENSP00000362187	ENSP00000342181	family with sequence similarity 102, member A; May play a role in estrogen action	signal recognition particle 72kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function	0.485
FAM102A	WDR44	ENSP00000362187	ENSP00000254029	family with sequence similarity 102, member A; May play a role in estrogen action	WD repeat domain 44	0.483
MDGA1	FAM102A	ENSP00000402584	ENSP00000362187	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	family with sequence similarity 102, member A; May play a role in estrogen action	0.403
MDGA2	FAM102A	ENSP00000382178	ENSP00000362187	MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity)	family with sequence similarity 102, member A; May play a role in estrogen action	0.403
SH3GL1	FAM102A	ENSP00000269886	ENSP00000362187	SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)	family with sequence similarity 102, member A; May play a role in estrogen action	0.512
SKAP1	FAM102A	ENSP00000338171	ENSP00000362187	src kinase associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells	family with sequence similarity 102, member A; May play a role in estrogen action	0.590

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