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STRINGSTRING
TGIF2LX TGIF2LX ZNF711 ZNF711 KLHL4 KLHL4 MEGF8 MEGF8 SH3BGRL SH3BGRL MMADHC MMADHC
"KLHL4" - kelch-like 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLHL4kelch-like 4 (Drosophila) (720 aa)    
Predicted Functional Partners:
ZNF711
zinc finger protein 711; Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C (761 aa)
      score_image     score_image   0.529
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism (296 aa)
            score_image   0.485
MEGF8
multiple EGF-like-domains 8 (2778 aa)
            score_image   0.481
SH3BGRL
SH3 domain binding glutamic acid-rich protein like (114 aa)
            score_image   0.446
TGIF2LX
TGFB-induced factor homeobox 2-like, X-linked; May have a transcription role in testis (241 aa)
            score_image   0.439
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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