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STRINGSTRING
MINOS1 MINOS1 SATL1 SATL1 MLKL MLKL IMMT IMMT CHCHD3 CHCHD3 APOOL APOOL ARHGAP40 ARHGAP40 LRRC28 LRRC28 NDUFB10 NDUFB10 COX5A COX5A
"APOOL" - apolipoprotein O-like in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APOOLapolipoprotein O-like (268 aa)    
Predicted Functional Partners:
MLKL
mixed lineage kinase domain-like; Required for the execution of programmed necrosis (471 aa)
            score_image   0.511
NDUFB10
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (172 aa)
      score_image         0.482
IMMT
inner membrane protein, mitochondrial (758 aa)
      score_image     score_image   0.460
MINOS1
mitochondrial inner membrane organizing system 1; May play a role in mitochondrial architecture (By similarity) (78 aa)
            score_image   0.450
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3; Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (227 aa)
      score_image     score_image   0.446
COX5A
cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (150 aa)
      score_image         0.430
LRRC28
leucine rich repeat containing 28 (367 aa)
            score_image   0.427
SATL1
spermidine/spermine N1-acetyl transferase-like 1 (632 aa)
            score_image   0.418
ARHGAP40
Rho GTPase activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (622 aa)
            score_image   0.410
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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