node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C22orf34 | PTPRT | ENSP00000395549 | ENSP00000362283 | chromosome 22 open reading frame 34 | protein tyrosine phosphatase, receptor type, T | 0.501 |
GRB2 | PTPRT | ENSP00000339007 | ENSP00000362283 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | protein tyrosine phosphatase, receptor type, T | 0.639 |
GRB2 | PXN | ENSP00000339007 | ENSP00000228307 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) | 0.898 |
GRB2 | STAT3 | ENSP00000339007 | ENSP00000264657 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.969 |
HPX | NENF | ENSP00000265983 | ENSP00000355955 | hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation | neudesin neurotrophic factor; Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme (By similarity) | 0.647 |
HPX | PTPRT | ENSP00000265983 | ENSP00000362283 | hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation | protein tyrosine phosphatase, receptor type, T | 0.470 |
NENF | HPX | ENSP00000355955 | ENSP00000265983 | neudesin neurotrophic factor; Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme (By similarity) | hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation | 0.647 |
NENF | PTPRT | ENSP00000355955 | ENSP00000362283 | neudesin neurotrophic factor; Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme (By similarity) | protein tyrosine phosphatase, receptor type, T | 0.546 |
PHLPP2 | PTPRN | ENSP00000348611 | ENSP00000295718 | PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.444 |
PHLPP2 | PTPRT | ENSP00000348611 | ENSP00000362283 | PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] | protein tyrosine phosphatase, receptor type, T | 0.444 |
PTPRN | PHLPP2 | ENSP00000295718 | ENSP00000348611 | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] | 0.444 |
PTPRN | PTPRT | ENSP00000295718 | ENSP00000362283 | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | protein tyrosine phosphatase, receptor type, T | 0.594 |
PTPRT | C22orf34 | ENSP00000362283 | ENSP00000395549 | protein tyrosine phosphatase, receptor type, T | chromosome 22 open reading frame 34 | 0.501 |
PTPRT | GRB2 | ENSP00000362283 | ENSP00000339007 | protein tyrosine phosphatase, receptor type, T | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.639 |
PTPRT | HPX | ENSP00000362283 | ENSP00000265983 | protein tyrosine phosphatase, receptor type, T | hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation | 0.470 |
PTPRT | NENF | ENSP00000362283 | ENSP00000355955 | protein tyrosine phosphatase, receptor type, T | neudesin neurotrophic factor; Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme (By similarity) | 0.546 |
PTPRT | PHLPP2 | ENSP00000362283 | ENSP00000348611 | protein tyrosine phosphatase, receptor type, T | PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] | 0.444 |
PTPRT | PTPRN | ENSP00000362283 | ENSP00000295718 | protein tyrosine phosphatase, receptor type, T | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.594 |
PTPRT | PXN | ENSP00000362283 | ENSP00000228307 | protein tyrosine phosphatase, receptor type, T | paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) | 0.921 |
PTPRT | SKAP2 | ENSP00000362283 | ENSP00000005587 | protein tyrosine phosphatase, receptor type, T | src kinase associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway | 0.511 |