node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAD8 | SLC29A3 | ENSP00000281182 | ENSP00000362285 | acyl-CoA dehydrogenase family, member 8; Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex | solute carrier family 29 (nucleoside transporters), member 3 | 0.751 |
ACADS | GCDH | ENSP00000242592 | ENSP00000222214 | acyl-CoA dehydrogenase, C-2 to C-3 short chain | glutaryl-CoA dehydrogenase; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive | 0.923 |
ACADS | SLC29A3 | ENSP00000242592 | ENSP00000362285 | acyl-CoA dehydrogenase, C-2 to C-3 short chain | solute carrier family 29 (nucleoside transporters), member 3 | 0.608 |
GCDH | ACADS | ENSP00000222214 | ENSP00000242592 | glutaryl-CoA dehydrogenase; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive | acyl-CoA dehydrogenase, C-2 to C-3 short chain | 0.923 |
GCDH | SLC29A3 | ENSP00000222214 | ENSP00000362285 | glutaryl-CoA dehydrogenase; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive | solute carrier family 29 (nucleoside transporters), member 3 | 0.683 |
SLC28A1 | SLC29A3 | ENSP00000286749 | ENSP00000362285 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3’-azido-3’-deoxythymidine (AZT) and 2’,3’-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective i [...] | solute carrier family 29 (nucleoside transporters), member 3 | 0.751 |
SLC28A1 | UPF2 | ENSP00000286749 | ENSP00000348708 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3’-azido-3’-deoxythymidine (AZT) and 2’,3’-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective i [...] | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.507 |
SLC28A2 | SLC29A3 | ENSP00000315006 | ENSP00000362285 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues | solute carrier family 29 (nucleoside transporters), member 3 | 0.766 |
SLC28A2 | UPF2 | ENSP00000315006 | ENSP00000348708 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.570 |
SLC28A3 | SLC29A3 | ENSP00000365413 | ENSP00000362285 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2-1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3’-azido-3’-deoxythymidine (AZT), ribavirin and 3-deazauridine | solute carrier family 29 (nucleoside transporters), member 3 | 0.770 |
SLC28A3 | UPF2 | ENSP00000365413 | ENSP00000348708 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2-1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3’-azido-3’-deoxythymidine (AZT), ribavirin and 3-deazauridine | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.499 |
SLC29A3 | ACAD8 | ENSP00000362285 | ENSP00000281182 | solute carrier family 29 (nucleoside transporters), member 3 | acyl-CoA dehydrogenase family, member 8; Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex | 0.751 |
SLC29A3 | ACADS | ENSP00000362285 | ENSP00000242592 | solute carrier family 29 (nucleoside transporters), member 3 | acyl-CoA dehydrogenase, C-2 to C-3 short chain | 0.608 |
SLC29A3 | GCDH | ENSP00000362285 | ENSP00000222214 | solute carrier family 29 (nucleoside transporters), member 3 | glutaryl-CoA dehydrogenase; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive | 0.683 |
SLC29A3 | SLC28A1 | ENSP00000362285 | ENSP00000286749 | solute carrier family 29 (nucleoside transporters), member 3 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3’-azido-3’-deoxythymidine (AZT) and 2’,3’-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective i [...] | 0.751 |
SLC29A3 | SLC28A2 | ENSP00000362285 | ENSP00000315006 | solute carrier family 29 (nucleoside transporters), member 3 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues | 0.766 |
SLC29A3 | SLC28A3 | ENSP00000362285 | ENSP00000365413 | solute carrier family 29 (nucleoside transporters), member 3 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2-1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3’-azido-3’-deoxythymidine (AZT), ribavirin and 3-deazauridine | 0.770 |
SLC29A3 | STX11 | ENSP00000362285 | ENSP00000356540 | solute carrier family 29 (nucleoside transporters), member 3 | syntaxin 11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network | 0.681 |
SLC29A3 | STXBP2 | ENSP00000362285 | ENSP00000221283 | solute carrier family 29 (nucleoside transporters), member 3 | syntaxin binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells | 0.740 |
SLC29A3 | UNC13D | ENSP00000362285 | ENSP00000207549 | solute carrier family 29 (nucleoside transporters), member 3 | unc-13 homolog D (C. elegans); Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells | 0.687 |