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CYP26C1 CYP26C1 PAX6 PAX6 SIX3 SIX3 PLP1 PLP1 BMP4 BMP4 POU3F4 POU3F4 SALL1 SALL1 SHH SHH PITX2 PITX2 SLIT3 SLIT3 SLIT1 SLIT1
"POU3F4" - POU class 3 homeobox 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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co-expression
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protein homology
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[Homology]
Score
POU3F4POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain (361 aa)    
Predicted Functional Partners:
PAX6
paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes (436 aa)
            score_image   0.945
PLP1
proteolipid protein 1; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (277 aa)
            score_image   0.920
SIX3
SIX homeobox 3; May be involved in visual system development (332 aa)
            score_image   0.897
SHH
sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] (462 aa)
            score_image   0.868
PITX2
paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) (324 aa)
            score_image   0.863
SALL1
sal-like 1 (Drosophila); Transcriptional repressor involved in organogenesis (By similarity) (1324 aa)
            score_image   0.815
CYP26C1
cytochrome P450, family 26, subfamily C, polypeptide 1; Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate) (522 aa)
            score_image   0.810
BMP4
bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) (408 aa)
            score_image   0.786
SLIT1
slit homolog 1 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (1534 aa)
            score_image   0.750
SLIT3
slit homolog 3 (Drosophila); May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors (1523 aa)
            score_image   0.747
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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