node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD2BP2 | SH3BGRL | ENSP00000304903 | ENSP00000362308 | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | SH3 domain binding glutamic acid-rich protein like | 0.644 |
CD2BP2 | SNRPF | ENSP00000304903 | ENSP00000266735 | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | small nuclear ribonucleoprotein polypeptide F; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Associated with snRNP U1, U2, U4/U6 and U5 | 0.968 |
CNGB1 | SH3BGRL | ENSP00000251102 | ENSP00000362308 | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | SH3 domain binding glutamic acid-rich protein like | 0.860 |
HMGN1 | SH3BGRL | ENSP00000370125 | ENSP00000362308 | high mobility group nucleosome binding domain 1; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity) | SH3 domain binding glutamic acid-rich protein like | 0.757 |
NSFL1C | SH3BGRL | ENSP00000418529 | ENSP00000362308 | NSFL1 (p97) cofactor (p47) | SH3 domain binding glutamic acid-rich protein like | 0.644 |
PSMA1 | PSMA5 | ENSP00000414359 | ENSP00000271308 | proteasome (prosome, macropain) subunit, alpha type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity) | proteasome (prosome, macropain) subunit, alpha type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | 0.999 |
PSMA1 | SH3BGRL | ENSP00000414359 | ENSP00000362308 | proteasome (prosome, macropain) subunit, alpha type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity) | SH3 domain binding glutamic acid-rich protein like | 0.644 |
PSMA5 | PSMA1 | ENSP00000271308 | ENSP00000414359 | proteasome (prosome, macropain) subunit, alpha type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | proteasome (prosome, macropain) subunit, alpha type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity) | 0.999 |
PSMA5 | SH3BGRL | ENSP00000271308 | ENSP00000362308 | proteasome (prosome, macropain) subunit, alpha type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | SH3 domain binding glutamic acid-rich protein like | 0.670 |
SCAF4 | SH3BGRL | ENSP00000286835 | ENSP00000362308 | SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) | SH3 domain binding glutamic acid-rich protein like | 0.655 |
SH3BGRL | CD2BP2 | ENSP00000362308 | ENSP00000304903 | SH3 domain binding glutamic acid-rich protein like | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | 0.644 |
SH3BGRL | CNGB1 | ENSP00000362308 | ENSP00000251102 | SH3 domain binding glutamic acid-rich protein like | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | 0.860 |
SH3BGRL | HMGN1 | ENSP00000362308 | ENSP00000370125 | SH3 domain binding glutamic acid-rich protein like | high mobility group nucleosome binding domain 1; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity) | 0.757 |
SH3BGRL | NSFL1C | ENSP00000362308 | ENSP00000418529 | SH3 domain binding glutamic acid-rich protein like | NSFL1 (p97) cofactor (p47) | 0.644 |
SH3BGRL | PSMA1 | ENSP00000362308 | ENSP00000414359 | SH3 domain binding glutamic acid-rich protein like | proteasome (prosome, macropain) subunit, alpha type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity) | 0.644 |
SH3BGRL | PSMA5 | ENSP00000362308 | ENSP00000271308 | SH3 domain binding glutamic acid-rich protein like | proteasome (prosome, macropain) subunit, alpha type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | 0.670 |
SH3BGRL | SCAF4 | ENSP00000362308 | ENSP00000286835 | SH3 domain binding glutamic acid-rich protein like | SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) | 0.655 |
SH3BGRL | SNRPF | ENSP00000362308 | ENSP00000266735 | SH3 domain binding glutamic acid-rich protein like | small nuclear ribonucleoprotein polypeptide F; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Associated with snRNP U1, U2, U4/U6 and U5 | 0.914 |
SH3BGRL | STAT6 | ENSP00000362308 | ENSP00000300134 | SH3 domain binding glutamic acid-rich protein like | signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling | 0.827 |
SH3BGRL | STUB1 | ENSP00000362308 | ENSP00000219548 | SH3 domain binding glutamic acid-rich protein like | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates- ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 th [...] | 0.646 |