node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLPP | CLPX | ENSP00000245816 | ENSP00000300107 | ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli); Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates | ClpX caseinolytic peptidase X homolog (E. coli); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP (By similarity) | 0.999 |
CLPP | TBX22 | ENSP00000245816 | ENSP00000362390 | ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli); Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates | T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis | 0.747 |
CLPX | CLPP | ENSP00000300107 | ENSP00000245816 | ClpX caseinolytic peptidase X homolog (E. coli); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP (By similarity) | ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli); Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates | 0.999 |
CLPX | TBX22 | ENSP00000300107 | ENSP00000362390 | ClpX caseinolytic peptidase X homolog (E. coli); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP (By similarity) | T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis | 0.626 |
EVX1 | TBX22 | ENSP00000419266 | ENSP00000362390 | even-skipped homeobox 1; May play a role in the specification of neuronal cell types | T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis | 0.622 |
EVX1 | TLE1 | ENSP00000419266 | ENSP00000365682 | even-skipped homeobox 1; May play a role in the specification of neuronal cell types | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.835 |
EVX1 | TLE2 | ENSP00000419266 | ENSP00000262953 | even-skipped homeobox 1; May play a role in the specification of neuronal cell types | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.824 |
EVX1 | TLE3 | ENSP00000419266 | ENSP00000452871 | even-skipped homeobox 1; May play a role in the specification of neuronal cell types | transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.835 |
EVX1 | TLE4 | ENSP00000419266 | ENSP00000365735 | even-skipped homeobox 1; May play a role in the specification of neuronal cell types | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.835 |
EVX1 | TLE6 | ENSP00000419266 | ENSP00000246112 | even-skipped homeobox 1; May play a role in the specification of neuronal cell types | transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila); As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity) | 0.779 |
EVX2 | TBX22 | ENSP00000312385 | ENSP00000362390 | even-skipped homeobox 2 | T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis | 0.622 |
EVX2 | TLE1 | ENSP00000312385 | ENSP00000365682 | even-skipped homeobox 2 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.824 |
EVX2 | TLE2 | ENSP00000312385 | ENSP00000262953 | even-skipped homeobox 2 | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.824 |
EVX2 | TLE3 | ENSP00000312385 | ENSP00000452871 | even-skipped homeobox 2 | transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.824 |
EVX2 | TLE4 | ENSP00000312385 | ENSP00000365735 | even-skipped homeobox 2 | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.824 |
EVX2 | TLE6 | ENSP00000312385 | ENSP00000246112 | even-skipped homeobox 2 | transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila); As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity) | 0.779 |
SMCP | TBX22 | ENSP00000357754 | ENSP00000362390 | sperm mitochondria-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis | 0.754 |
TBX22 | CLPP | ENSP00000362390 | ENSP00000245816 | T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis | ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli); Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates | 0.747 |
TBX22 | CLPX | ENSP00000362390 | ENSP00000300107 | T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis | ClpX caseinolytic peptidase X homolog (E. coli); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP (By similarity) | 0.626 |
TBX22 | EVX1 | ENSP00000362390 | ENSP00000419266 | T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis | even-skipped homeobox 1; May play a role in the specification of neuronal cell types | 0.622 |