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STRINGSTRING
TLE3 TLE3 EVX2 EVX2 TLE6 TLE6 EVX1 EVX1 TLE1 TLE1 SMCP SMCP TLE4 TLE4 TBX22 TBX22 TLE2 TLE2 CLPX CLPX CLPP CLPP
"TBX22" - T-box 22 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TBX22T-box 22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis (520 aa)    
Predicted Functional Partners:
SMCP
sperm mitochondria-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) (116 aa)
            score_image   0.754
CLPP
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli); Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (277 aa)
            score_image   0.747
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) (772 aa)
            score_image   0.641
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (770 aa)
            score_image   0.626
CLPX
ClpX caseinolytic peptidase X homolog (E. coli); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP (By similarity) (633 aa)
            score_image   0.626
EVX1
even-skipped homeobox 1; May play a role in the specification of neuronal cell types (407 aa)
            score_image   0.622
EVX2
even-skipped homeobox 2 (476 aa)
            score_image   0.622
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) (773 aa)
            score_image   0.612
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) (743 aa)
            score_image   0.612
TLE6
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila); As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity) (572 aa)
            score_image   0.612
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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